Dr Suong Ngo

Dr Suong Ngo
 Position Senior Lecturer in Pharmacology
 Org Unit School of Animal and Veterinary Science
 Email suong.ngo@adelaide.edu.au
 Telephone +61 8 8313 0660
 Location Floor/Room G9 ,  Corridor Building ,   Roseworthy

  • Biography/ Background

    Welcome to my Adelaide Uni homepage. I am a Senior Lecturer in Pharmacology in the School of Animal and Veterinary Sciences, with teaching and research interests in the Molecular Pharmacology & Toxicology, Pharmaceutical Science, Pharmacogenomics/Pharmacogenetics, and Quality Use of Medicines areas. My research focuses on: 1) Xenobiotic disposition in Australian Marsupials 2) Molecular mechanism of drug-interactions involving complementary medicines, with a focus on cytochrome P450 CYP enzymes and P-glycoproteins 3) Appropriate and safe use of OTC medicines 4) Generic substitution - assessing in vitro bioequivalence of multiple generic NTI medicines. Recently I have developed teaching and research interests in genetic polymorphisms and their association to variable response/toxicity to anticancer drugs used in advanced breast and colorectal cancer patients.

  • Qualifications

    Bachelor of Pharmacy (UniSA) 1998

     

    Bachelor of Pharmacy Honours (UniSA) 1999

     

    Ph.D. (UniSA) 2004

  • Awards & Achievements

    2008-2013, ASCEPT ASM Editorial Member

    2008, Lecturer of the year, Faculty of Education, Health & Science, CDU

     

    2000, APA - Australian Postgraduate Award

     

    Grants

     

    2008, SNT Ngo, R Rumble, et al $72,000, CDU Allied Health Group, Infrastructure grant, University

     

    2008, SNT Ngo, T Barnes, $10,000, CDU Project grant, University

     

    2007, SNT Ngo, T Barnes, $7,800, CDU Project grant, University

     

    2005, SNT Ngo, A Davey, A Evans,  $17,600, UniSA Australian Competitive Grant (ACG) Development Scheme, Project grant, University

     

    2005, A Davey, SNT Ngo, R Milne, $18,500, UniSA Australian Competitive Grant (ACG) Development Scheme, Project grant, University

     

  • Teaching Interests

    Pharmacology & Toxicology

  • Research Interests

    Current projects:  

              
    1. Molecular insights into xenobiotic disposition in Australian marsupials: While most animals tend to select food low in potentially toxic chemicals, several Australian marsupials rely on eucalyptus leaves as a major or only food source. In order to ingest and absorb such large quantities of toxic plant secondary metabolites in these leaves, specialist eucalyptus feeders such as the koala must have evolved highly specialised detoxification mechanism involved several liver enzyme systems. The project will examine the dietary effect of eucalyptus terpenes on the induction of CYP4A, peroxisomal Acyl CoA Oxidases and other CYPs in Australian marsupials. The transcriptional regulatory role of the nuclear receptor PPAR-alpha will also be investigated. The project will contribute to the knowledge of the metabolic capacity of Australian marsupials, especially at the molecular level that is limited at present.

     

    2. Appropriate and safe use of OTC medicines: The aim of the project is to investigate whether patients are well informed about OTC they take, with a focus on non-prescription analgesics, utilizing a cross-sectional study involving multiple item self-administered anonymous questionnaires and stratified samples of patients from community pharmacies. The project aims to identify various pathways that may be used for conveying of safe and accurate information to the patients.  

                      
    3. Mechanism of herb-drug interaction - The effects of St John's Wort (SJW) on membrane transport proteins and drug metabolising enzymes. The project examines the molecular mechanism by which SJW changes the way the body handles conventional medicines, particularly examining the factors responsible for drug up-take and handling along different regions of the intestines, the liver and kidneys. The project involves extraction and quantification of active constituents of SJW, animal studies, and analyses of CYP3A protein and mRNA expression utilising molecular biology techniques.

      

    4. Generic substitution - assessing in vitro bioequivalence of multiple generic medicines: The project aims to assess in vitro bioequivalence of multiple generic medicines by dissolution test, with a focus on narrow therapeutic index drugs in which a relatively small change in systemic absorption can result in marked changes in therapeutic effects and toxicity.                   

  • Publications

    Guilding C, White PJ, Kelly-Laubscher R, Keonig J, Babey A-M, Tucker S, Kelly J, Gorman L, Aronsson P, Hawes M, Ngo SNT, Mifsud J, Werners A, Hinton T, Khan F,  Angelo T. Defining and unpacking the core concepts of pharmacology: A global initiative. British Journal of Pharmacology, 1-18; 2023.

    Santiago M, Davis EA, Hinton T, Angelo T, Shield A, Babey A-M, Kemp-Harper B, Maynard G, Al-Sallami HS, Musgrave IF, Fernandes LB, Ngo SNT, Christopoulos A, White PJ. Defining and unpacking the core concepts of pharmacology education. Pharmacology Research and Perspectives, 9:e00894; 2021.

    White PJ, Davis EA, Santiago M, Angelo T, Shield A, Babey A-M, Kemp-Harper B, Maynard G, Al-Sallami HS, Musgrave IF, Fernandes LB, Ngo SNT, Hinton T. Identifying the core concepts of pharmacology education. Pharmacology Research and Perspectives, 9(4):e00836; 2021.

    Ngo SNT, Williams DB. Protective effect of isothiocyanates from cruciferous vegetables on breast cancer: Epidemiological and preclinical perspectives. Anti-Cancer Agents in Medicinal Chemistry, 21(11):1413-1430; 2021.

     

    Ngo SNT. Can multiple choice questions assess application of knowledge in pharmaceutical science teaching? Pharmacy Education, 18(1):202-206; 2018.

     

    Ngo SNT, Addison CJ. Are COX-2 selective NSAIDs associated with less GI, renal, and cardiovascular side effects: Evidence from animals treated with NSAIDs. Annual Research and Review in Biology, 29(6):1-8; 2018.

     

    Ngo SNT, Schumann AC. Drug metabolism and disposition in Australian marsupial koala (Phascolarctos cinereus). Annual Research and Review in Biology, 28(4):1-10; 2018.

     

    Bishop BF, Ngo SNT. Non-steroidal anti-inflammatory drugs as chemopreventive agents: Evidence from cancer treatment in domestic animals. Annual Research and Review in Biology, 26(1):1-13; 2018.

     

    Wright M, Ngo SNT. Management of Eastern Brown and Tiger snake envenomation in domestic animals in South Australia. Annual Research and Review in Biology, 25(4):1-12; 2018.

     

    Wong S, Ngo SNT. Use of in vitro dissolution testing to assess multiple generic metformin tablets. Journal of Pharmaceutical Research International, 21(4):1-9; 2018.


    Ngo SNT. Reduction of UV-induced skin tumours in hairless mice by topical non-steroidal anti-inflammatory drugs. Journal of Cancer and Tumour International, 7 (2):1-7; 2018.

     

    Ngo SNT. Are isothiocyanates from cruciferous vegetables potential therapeutic agents for breast cancer. International Journal of Biological Engineering, 6(1):7-11; 2016.

     

    Ngo SNT, Leong WS. Uses of non-prescription ibuprofen by consumers from community pharmacies in South Australia. Journal of Pharmacy Practice and Research, 46(1):91-93; 2016.

     

    Ngo SNT, McKinnon RA. PPAR-alpha cloning, expression, and characterisation. Methods in Molecular Biology (Clifton NJ), 952: 7-34; 2013.

     

    Ngo SNT, Stupans I, McKinnon RA. Generic substitution in the treatment of epilepsy: Patient attitudes and perceptions. Epilepsy & Behavior 26(1): 64-66; 2013.

     

    El-Merhibi A, Ngo SNT, Crittenden TA, Marchant CL, Stupans I, McKinnon RA. Cytochrome P450 CYP3A in marsupials: Cloning and identification of the first CYP3A subfamily member, isoform 3A70 from Eastern grey kangaroo (Macropus giganteus). Gene 506: 423-428; 2012.

     

    Ibrahim R, McKinnon RA, Ngo SNT. Knowledge and perceptions of community patients about generic medicines. Journal of Pharmacy Practice and Research 42(4): 283-286; 2012.

    Milic NL, Ngo SNT, Marchant CL, Height TA, McKinnon RA. Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii). Comparative Biochemistry and Physiology C Toxicology & Pharmacology 153: 60-66; 2011.
     
    El-Merhibi A, Ngo SNT, Crittenden TA, Marchant CL, Stupans I, McKinnon RA. Cytochrome P450 CYP3A in marsupials: Cloning and characterisation of the second identified CYP3A subfamily member, isoform 3A78 from koala (Phascolarctos cinereus). Comparative Biochemistry and Physiology C Toxicology & Pharmacology 154(4): 367-376; 2011. 
     
    Ngo SNT, Williams DB, Cobiac L, Head RJ. Rosemary and cancer prevention - Preclinical perspectives. Critical Reviews in Food Science and Nutrition 51(10): 946-954; 2011.
     
    Ngo SNT, McKinnon RA, Stupans I. Correlation between peroxisome proliferation and up-regulation of cytochrome P450 CYP4A and peroxisomal beta-oxidation fatty acyl CoA oxidases (AOX) in the koala (Phascolarctos cinereus). Gene Expression to Genetical Genomics 3: 1-6; 2010.
     
    Ngo SNT, Stupans I, Leong WS, Osman M. Appropriate use of non-prescription ibuprofen: a survey of patients’ perceptions and understanding. International Journal of Pharmacy Practice 18(1): 63-65; 2010.
     
    Ngo SNT, Barnes T. Is there variability in drug release and physical characteristics of amiodarone chloride from different commercially available tablets: Possible therapeutic implications? International Journal of Pharmacy Practice 18(4): 245-248; 2010.
     
    Kong S, Ngo SNT, McKinnon RA, Stupans I. Cloning and expression of koala (Phascolarctos cinereus) liver Cytochrome P450 reductase. Comparative Biochemistry and Physiology C Toxicology & Pharmacology 150: 1-9; 2009. 
     
    Turkanovic J, Ngo SNT, Milne RW. Effect of St John's wort on the disposition of fexofenadine in the isolated perfused rat liver. Journal of Pharmacy and Pharmacology 61(8): 1037-1042; 2009.
     
    Jones BJ, El-Merhibi A, Ngo SNT, Stupans I, McKinnon RA. Hepatic cytochrome P450 enzymes belonging to the CYP2C subfamily from an Australian marsupial, the koala (Phascolarctos cinereus). Comparative Biochemistry and Physiology C Toxicology & Pharmacology 148(3): 230-237; 2008.
     
    El-Merhibi A, Ngo SNT, Jones BJ, McKinnon RA. Molecular insights into xenobiotic disposition in Australian marsupials. The Australasian Journal of Ecotoxicology 13(2): 53-64; 2008.
     
    Ngo SNT, Mckinnon RA, Stupans I. Morphological examination and quantification of hepatic peroxisomes in the koala (Phascolarctos Cinereus) by electron microscopy. Comparative Biochemistry and Physiology A Molecular & Integrative Physiology 151(1): S50; 2008.
     
    Ngo SNT, Mckinnon RA, Stupans I. Correlation between peroxisome proliferation and up-regulation of cytochrome P450 CYP4A and peroxisomal beta-oxidation fatty acyl CoA oxidases (AOX) in the koala (Phascolarctos Cinereus). Comparative Biochemistry and Physiology A  Molecular & Integrative Physiology  151(1): S22-23; 2008.
     
    Ngo SNT, Phan TT, Trec S, Heng SH, McKinnon RA. Molecular Mechanism of Drug Interactions involving St John’s Wort: Impact of Exposure Dose and Time on Up Regulation of CYP3A across Different Tissues. Proceedings of the 17th International Symposium on Microsomes and Drug Oxidations, Saratoga, NY, USA, July 2008, p83-86; 2008.
     
    Phan TT, Heng SH, Abarno A, McKinnon RA, Ngo SNT. Induction of cytochrome P450 CYP3A by St John’s Wort in the rat liver and intestine, Integrative Medicine Insights 2: 73-81; 2007.
     
    Ngo SNT, Williams DB, Cobiac L, Head RJ. Does garlic reduce risk of colorectal cancer? a systematic review. Journal of Nutrition 137(10): 2264-2269; 2007.
     
    Ngo SNT, McKinnon RA, Stupans I. Hepatic nuclear receptor PPARalpha in the koala (Phascolarctos cinereus): cloning and molecular characterization. Comparative Biochemistry and Physiology C Toxicology & Pharmacology 146: 375-382; 2007.
     
    Ngo SNT. 'When do differences in dissolution profiles predict clinical problems?'. Journal of Clinical Pharmacy and Therapeutics 32: 111-112; 2007.
     
    Ngo SNT, McKinnon RA, Stupans I. Cloning and characterisation of liver CYP4A15 from the koala (Phascolarctos Cinereus). Gene 376(1): 123-32; 2006.
     
    Tong Y, Zhang R, Ngo SNT, Davey AK. Alteration of fexofenadine disposition in the isolated perfused rat liver following injection of bacterial lipopolycaccharide. Clinical Experimental Pharmacology and Physiology 33: 685-689; 2006.
     
    Ngo SNT, McKinnon RA, and Stupans I. Identification and cloning of two forms of liver peroxisomal fatty Acyl CoA Oxidases from the koala (Phascolarctos Cinereus).  Gene 309: 91-99; 2003.
     
    Ngo SNT, McKinnon RA, and Stupans I. The effects of Eucalyptus Terpenes on Microsomal Cytochrome P450 CYP4A, Peroxisomal Acyl CoA Oxidase (AOX) and Peroxisome Proliferator Activated Receptor Alpha (PPAR-a) in the Common Brush tail Possum Liver, Trichosurus vulpecular. Comparative Biochemistry and Physiology C Toxicology & Pharmacology 127: 327-334; 2003.
     
    Ngo SNT, McKinnon RA, and Stupans I. Cytochrome P450 4A, peroxisomal enzymes nicotinamide cofactors in koala liver. Comparative Biochemistry and Physiology C Toxicology & Pharmacology 136(2): 165-173; 2000.

     

    Publications in GenBank, National Centre for Biotechnology Information (NCBI):

     

    Milic N, Ngo SNT, McKinnon RA. Macropus eugenii lung cytochrome P450, family 4, subfamily B, polypeptide 1 (CYP4B1) mRNA, complete cds. GenBank, ncbi.nlm.nih.gov, Accession number HM146305; 2010.

     

    Milic N, Ngo SNT, McKinnon RA. Macropus eugenii lung cytochrome P450, family 4, subfamily B, polypeptide 3 (CYP4B3) mRNA, complete cds. GenBank, ncbi.nlm.nih.gov, Accession number HM146306; 2010.

     

    El-Merhibi A, Ngo SNT, McKinnon RA. Macropus giganteus cytochrome P450, family 3, subfamily A, polypeptide 70 (CYP3A70) mRNA, complete cds. GenBank, ncbi.nlm.nih.gov, Accession number HQ595723; 2010.

     

    El-Merhibi A, Ngo SNT, McKinnon RA. Phascolarctos cinereus cytochrome P450, family 3, subfamily A, polypeptide 78 (CYP3A78) mRNA, complete cds. GenBank, ncbi.nlm.nih.gov, Accession number HQ595724; 2010.

     

    Kong S, Ngo SNT, McKinnon RA, Stupans I. Phascolarctos cinereus cytochrome P450 reductase isoform 1 mRNA complete cds. GenBank, ncbi.nlm.nih.gov, Accession number EU924792; 2008.

     

    Kong S, Ngo SNT, McKinnon RA, Stupans I. Phascolarctos cinereus cytochrome P450 reductase isoform 2 mRNA complete cds. GenBank, ncbi.nlm.nih.gov, Accession number EU924793; 2008.

     

    Ngo SNT, McKinnon RA, and Stupans I. Koala liver Acyl-CoA oxidase type 1 (AOXI) full-length cDNA. GenBank, ncbi.nlm.nih.gov, Accession number AF463453; 2001.

     

    Ngo SNT, McKinnon RA, and Stupans I. Koala liver Acyl-CoA oxidase type 2 (AOXII) full-length cDNA. GenBank, ncbi.nlm.nih.gov, Accession number AF463454; 2001.

     

    Ngo SNT, McKinnon RA, and Stupans I. Koala liver Peroxisome Proliferator Activated Receptor Alpha (PPARα) full-length cDNA. GenBank, ncbi.nlm.nih.gov, Accession number AF463455; 2001.

     

    Ngo SNT, McKinnon RA, and Stupans I.  Koala Liver Cytochrome P450 CYP4A15 complete cDNA without the coding region for the last 10 amino acids before the stop codon. GenBank, ncbi.nlm.nih.gov, Accession number AF463456; 2001.

     

    Ngo SNT, McKinnon RA, and Stupans I. Koala liver Cytochrome P450 CYP4A15 partial cDNA. GenBank, ncbi.nlm.nih.gov, Accession number AF252263; 2000.

     

     

  • Professional Associations

    Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) - Society member.

     

    Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) - Equity Diversity and Inclusion EDI Committee Member.

     

    Australasian Pharmaceutical Science Association (APSA) - Member.

     

    Population Approach Group of Australia and New Zealand (PAGANZ) - Member.

     

    British Pharmacological Society (BPS) - Member.

     

    ASCEPT Pharmacogenomics SIG - Committee member.

     

    ASCEPT Education SIG - Committee member.

     

    ASCEPT Clinical Pharmacology SIG - Committee member.

     

    Adelaide Pharmacology Group (APG) - Member.

  • Community Engagement

    ...

The information in this directory is provided to support the academic, administrative and business activities of the 成人大片. To facilitate these activities, entries in the University Phone Directory are not limited to University employees. The use of information provided here for any other purpose, including the sending of unsolicited commercial material via email or any other electronic format, is strictly prohibited. The University reserves the right to recover all costs incurred in the event of breach of this policy.

Entry last updated: Saturday, 4 Nov 2023

To link to this page, please use the following URL:  /directory/suong.ngo