成人大片

Non-nutritive sweeteners are often perceived as healthier than sugar, but new findings have confirmed new ways they may interact with sugar handling in the body.

Researchers from the 成人大片 have examined the impact sweeteners, like Splenda, have on the ability to control blood glucose levels.

Previous research has linked the habitual and high intake of sweeteners to increased occurrence of type 2 diabetes.

鈥淚n this proof-of-concept study, we wanted to discover how non-nutritive sweeteners like sucralose (Splenda) and acesulfame-K might alter sugar handling,鈥� said Associate Professor Richard Young, Senior Research Fellow, Adelaide Medical School, 成人大片.

鈥淪pecifically, whether these sweeteners interact with sweet sensing pathways in the gut that govern the rate of sugar uptake directly, or indirectly through effects on gut bacteria.

鈥淯sing antibiotics, we cleared the gut bacteria of half of the mice, and then over two weeks, gave sucralose and acesulfame-K in drinking water.鈥�

The mice that received the sweeteners absorbed sugar at a faster rate from their gut compared to those who didn鈥檛, regardless of whether they were given antibiotics, showing that these sweeteners directly affected sugar uptake in the intestine. Their administration over two weeks, however, did not change overall blood sugar responses.

鈥淭hese findings go a long way to answering some of the fundamental questions we have around the effects of non-nutritive sweeteners and shows that despite the misconception that they are metabolically inert, their habitual high intake can alter distinct mechanisms of sugar handling,鈥� said Dr Braden Rose, Early Career Postdoctoral Researcher, Adelaide Medical School, 成人大片.

The research team, which included members of the University鈥檚 Centre for Research Excellence in Translating Nutritional Science to Good Health and Nutrition, will now move to clinical testing.

Researchers were also members of the Lifelong Health theme at South Australian Health and Medical Research Institute and published the results of a two-week preclinical study in .