成人大片

Osteoarthritis is the degeneration of cartilage and other tissues in joints and is the most common form of arthritis in Australia, with one in five people over the age of 45 having the condition.

It is a long-term and progressive condition which affects people鈥檚 mobility and has historically had no cure. Its treatment cost the Australian health system an estimated $3.9 billion in 2019-20.

Often described as a 鈥榳ear and tear鈥� condition, factors such as ageing, obesity, injury and family history contribute to the progression of osteoarthritis.

成人大片 researchers discovered a novel population of stem cells 鈥� marked by the Gremlin 1 gene 鈥� responsible for the progression of osteoarthritis.

Treatment with fibroblast growth factor 18 (FGF18) stimulated the proliferation of Gremlin 1 cells in joint cartilage in mice, leading to significant recovery of cartilage thickness and reduced osteoarthritis.

Gremlin 1 cells present opportunities for cartilage regeneration and their discovery will have relevance to other forms of cartilage injury and disease, which are notoriously challenging to repair and treat.

It challenges the categorisation of osteoarthritis as wear and tear.

鈥淭he findings of our study reimagine osteoarthritis not as a 鈥榳ear and tear鈥� condition but as an active, and pharmaceutically reversible loss of critical articular cartilage stem cells,鈥� said the 成人大片鈥檚 Dr Jia Ng from the Adelaide Medical School, who co-led the study which is published in the journal .

鈥淲ith this new information, we are now able to explore pharmaceutical options to directly target the stem cell population that is responsible for the development of articular cartilage and progression of osteoarthritis.鈥�

While Dr Ng describes current treatments for osteoarthritis as a 鈥淏and-Aid approach鈥�, this new understanding could lead to a pharmaceutical treatment that reverses osteoarthritis and helps to address health outcomes associated with the disease.

鈥淜nown comorbidities of osteoarthritis include heart, pulmonary, and kidney disease, mental and behavioural conditions, diabetes, and cancer,鈥� said Dr Ng.

鈥淥ur study suggests that there may be new ways to treat the disease rather than just the symptoms, leading to better health outcomes and quality of life for people who suffer from osteoarthritis.鈥�

Though this discovery is limited to animal models, Dr Ng said there are genetic similarities to human samples, and human trials are ongoing.

鈥淲e look forward to the outcome of these trials and to contribute to the better understanding of a pharmaceutical mechanism to treat osteoarthritis,鈥� she said.

Results of a five-year clinical trial study using FGF18, known clinically as Sprifermin, were published in 2021 with potential long-term clinical benefit and no safety concerns.

Phase 3 of the Sprifermin trial is ongoing, and researchers envision public access to this treatment soon.