成人大片

A cutting-edge DNA vaccine designed by 成人大片 researchers and manufactured in South Australia targeting the highly-transmissible Omicron COVID-19 variant 鈥� and can be easily adapted to future variants 鈥� is starting human trials this week.

The vaccine has been manufactured by the FDA-approved BioCina facility at Thebarton, trialled at the Royal Adelaide Hospital in partnership with PARC Clinical Services and SA Pathology, with research undertaken at the 成人大片 and Basil Hetzel Institute for Translational Health Research at The Queen Elizabeth Hospital precinct, and supported by The Hospital Research Foundation Group.

This is one of the few vaccines worldwide targeting the Omicron variant, whereas Pfizer, AstraZeneca, Moderna and Novavax vaccines target the original strain of the virus. DNA vaccines require simple engineering design modifications that can be made quickly to adapt to future variants, as opposed to MRNA-based vaccines, which are more complicated to make.

Lead investigator Associate Professor Branka Grubor-Bauk, Head of Viral Immunology at the 成人大片鈥檚 Adelaide Medical School, is calling on volunteers who are over the age of 18, triple vaccinated more than three months ago and have not had COVID-19, to put their hand up for the trial.

鈥淲e need to continue developing 鈥榥ext generation' COVID-19 vaccines because the virus will continue to mutate, particularly in countries with low vaccination rates and high rates of uncontrolled transmission,鈥� Associate Professor Grubor-Bauk said.

鈥淎s we live with COVID-19, we still have vulnerable populations at risk of severe disease.

鈥淚t is vitally important to evaluate variant-specific booster vaccines.鈥�

The vaccine will be administered using a needle-free device from American company Pharmajet.

The device delivers a micro-jet spray of liquid, which goes under the skin and is painless.

鈥淲e need to continue developing 鈥榥ext generation' COVID-19 vaccines because the virus will continue to mutate, particularly in countries with low vaccination rates and high rates of uncontrolled transmission."Associate Professor Branka Grubor-Bauk

Professor Eric Gowans, National Health and Medical Research Council Senior Research Fellow at the University鈥檚 Adelaide Medical School, who is co-leading the trial, added: 鈥淎nother advantage of this vaccine is its stability.

"It can be shipped at room temperature, stored for five years and manufactured in existing facilities en-masse.鈥�

The University鈥檚 Deputy Vice Chancellor and Vice-President (Research), Professor Anton Middelberg applauded the collaboration between the University鈥檚 researchers and BioCina.

鈥淲orking with our industry partners, we aim to build a new expert capability that will help contain the spread of the Omicron COVID-19 variant, and other variants that may evolve in the future,鈥� Professor Middelberg said.

鈥淭he ability to develop and manufacture the vaccine in existing facilities here in South Australia ensures we can secure our vaccine supply to respond to COVID-19 or any other future pathogen threats.鈥�

SA Pathology鈥檚 Associate Professor Pravin Hissaria, Clinical Immunologist and Immunopathologist at the Immunology Department, Royal Adelaide Hospital and the Principal Clinical Investigator of this trial, said the development of highly effective vaccines had been the most effective strategy in containing COVID-19.

鈥淚t is important that we continue to innovate and adapt to the evolving viral strains and deliver precise and effective vaccines,鈥� Associate Professor Hissaria said.

The Hospital Research Foundation Group has been funding the team鈥檚 vaccine development for the past 10 years and has been pivotal in helping it reach this point, with the ability to pivot quickly to new viruses and variants.

鈥淚t is a credit to South Australia that this vaccine has advanced so quickly and with such efficient technology,鈥� Paul Flynn, CEO of The Hospital Research Foundation Group, said.

鈥淭his trial will ultimately determine if the vaccine is safe, but I encourage South Australians interested in participating to put their trust in a respected, safe, peer-reviewed team like the 成人大片鈥檚 which has a proven track record in DNA vaccines.鈥�

How to participate: Visit for more information. Ethics and Governance approvals are in place.