成人大片

Researchers from the 成人大片 and the Radboud University Medical Centre in the Netherlands have repurposed an arthritis drug to restrict the use of antibiotics in the treatment of side effects caused by blood cancer, including leukaemia, lymphoma and myeloma.

Anakinra - a biologic drug that helps to decrease inflammation in rheumatoid arthritis and other inflammatory diseases 鈥� was found to have strengthened the gut lining and inhibited inflammation in rodents that were treated with chemotherapy.

This minimises the spread of bacteria from the gut to the blood stream, which is a common cause of infection and can be serious for people with weakened immune systems as a result of chemotherapy or other cancer treatments.

Lead author, 成人大片 cancer research fellow, Dr Hannah Wardill, said the results had the potential to be an important breakthrough given the risks of developing a tolerance to antibiotics.

鈥淲e were able to show in a rodent model that the drug Anakinra improved the integrity of the gut lining,鈥� Dr Wardill said.

鈥淎ntibiotics are the cornerstone of infection control in people with blood cancer, but they aren鈥檛 without their challenges.

鈥淓xcessive antibiotic use not only contributes to the development of antibiotic resistance, but also increases the risk of chronic complications, especially in people undergoing stem cell transplantation.鈥�

About 1.24 million blood cancer cases occur worldwide annually, while about 18,000 Australians were newly diagnosed last year. Blood cancers 鈥� such as leukaemia, lymphoma and myeloma - have increased by 40 per cent in the past decade.

Senior author and consultant hematologist at Radboud University Medical Centre, Professor Nicole Blijlevens, said a greater understanding of where infections originated led to finding alternative solutions to controlling bacteria.

鈥淲hile we used to think infections predominantly came from external sources like hospital surfaces and equipment, we now know that they mainly come from inside the person鈥檚 gut,鈥� Professor Blijlevens said.

鈥淭his has refocused our attention to how we can prevent these bacteria from moving from the gut to the blood.

鈥淲e showed that this drug - which is usually used to control rheumatoid arthritis 鈥� was not associated with any adverse events in people undergoing high dose chemotherapy.

鈥淔or decades, we have relied on antibiotics to prevent infection, but this new work suggests there may be alternatives to minimise our reliance on antibiotics.

鈥淲e must find ways to restrict antibiotic use, especially in cancer care, but we must do this cautiously and based on the right evidence.鈥�

Anakinra has been approved for use in Australia and the Netherlands for arthritis, and is currently under investigation in the Netherlands for use in cancer care.

The full study has been published in peer-reviewed open access journal .