Funding support to discover ways to block the migration of T-cells responsible for MS

T-cell illustration

成人大片 Research Fellow, Dr Iain Comerford has secured funding from Multiple Sclerosis Australia to further his research into the factors that influence specific immune cell (T cell) migration into the bloodstream and the brain in people who have MS.

鈥淭his is fundamental research to help us understand the factors that allow the T cells responsible for inflammation, to enter in the central nervous system,鈥 Dr Comerford says.

鈥淭he tricky thing is, not all T cells are alike, so we are trying to differentiate between those that cause the inflammatory response and those that don鈥檛, and ascertain the markers that make them different,鈥 he says.

Dr Comerford will be researching ways to identify unique combinations of surface markers and migratory mechanisms to build a better understanding of the actions of inflammatory and regulatory T cells.

鈥淥nce we better understand those differences, there is huge potential to develop therapies to block the action of inflammatory T cells, preventing their migration into the bloodstream and the central nervous system and at the same time protecting the regulatory T cells.

鈥淭he tricky thing is, not all T cells are alike, so we are trying to differentiate between those that cause the inflammatory response and those that don鈥檛, and ascertain the markers that make them different.鈥Dr Iain Comerford

鈥淭his may go some way to preventing the debilitating impacts of MS.鈥

Dr Comerford has been awarded $390,000 to continue his research in the , one of 26 recipients from universities and research centres across the country.

Still without a cure, MS is a chronic auto-immune disease affecting more than 25,000 Australians.

Tagged in MS research, Multiple Sclerosis, MS Australia, T cells, news brief, News in brief, research