成人大片

New research shows that the more a baby weighs at birth relative to its gestational age the higher the risk they will suffer from childhood food allergy or eczema, although not hay fever.

Dr Kathy Gatford from the 成人大片鈥檚 Robinson Research Institute led a team of scientists that carried out a systematic review assessing past studies in humans. After screening more than 15,000 studies, they identified 42 that included data on more than two million allergy sufferers.

鈥淲e analysed the associations between birth weight, corrected for gestational age, and the incidence of allergic diseases in children and adults,鈥� says Dr Gatford.

鈥淔or each kilogram increase in birth weight there was a 44 per cent increase in the risk that a child had food allergies or a 17 per cent increase in the risk that they had eczema.

鈥淲e found that increased birth weight has no influence on the risk of childhood hay fever.鈥�

鈥淚t is increasingly clear that genetics alone do not explain risks of developing allergies..." Kathy Gatford

Published in the , the researchers analysed studies that included over 2.1 million people affected by allergic dermatitis, commonly known as eczema, nearly 70,000 people affected by food allergies and over 100,000 people with allergic rhinitis or hay fever. Most of the studies were in children from developed countries and most were European.

鈥淎llergic diseases including eczema, hay fever, food allergies, anaphylaxis and asthma are estimated to affect 30鈥�40 per cent of the world鈥檚 population,鈥� says Dr Gatford.

鈥淚t is increasingly clear that genetics alone do not explain risks of developing allergies, and that environmental exposures before and around birth can program individuals to increased or decreased risk of allergies,鈥� says Dr Gatford.

鈥淎lthough restricted growth before birth 鈥� intra-uterine growth restriction (IUGR) 鈥� is associated with increased risks of many diseases in later life, it appears to protect a child against the risk of developing allergic responses.

鈥淭he main message for mums is that big babies are at increased risk of allergy, so mothers with big babies should seek advice on modifying environmental factors to reduce those risks.鈥�

Most of the allergies in these studies were assessed in young children. The researchers say further studies investigating allergies in older children, adolescents and adults are needed to help inform how and when restricting intra-uterine growth affected a person鈥檚 immune development and their susceptibility to allergic disease.

The study was initiated and planned by former 成人大片 PhD student Dr Amy Wooldridge, now based at the University of Alberta in Edmonton, Canada.