成人大片

• Biography/ Background

  Stefan Hiendleder studied Animal Science 1982-1987 at Justus-Liebig University (JLU) of Giessen, Germany where he obtained a PhD (Dr.agr.) working on sheep endocrinology and cell metabolism in 1989. He was appointed Assistant Professor Animal Breeding and Genetics at JLU in 1990. After sabbaticals at the Academy of Sciences, Kazakhstan (1991) and the University of Saskatchewan, Canada (1993) he obtained a habilitation degree in Animal Genetics (Dr.agr.habil.) with a thesis on 'Isolation and Characterization of QTL Candidates in Ruminants' in 1996. He worked at JLU as Associate Professor until joining the Molecular Animal Breeding and Biotechnology Group at the Gene Center of the Ludwig Maximilian University (LMU) in Munich, Germany in 2001. Dr. Hiendleder focused on the emerging field of Epigenetics and completed a second habilitation degree in Reproductive Biotechnology and Functional Genomics (Dr.med.vet.habil.) with the thesis ‘Non-Mendelian Effects in Animal Biotechnology'. He was appointed JS Davies Professorial Fellow 2005-2020 and continues to investigate non-mendelian genetic and epigenetic effects on embryo-fetal development and postnatal phenotype in the School of Animal and Veterinary Sciences, Davies Research Centre and the Robinson Research Institute.

• Qualifications

  Dr.med.vet.habil. (Habilitation) Ludwig Maximilian University Munich, Germany

  Dr.agr.habil. (Habilitation) Justus-Liebig University Giessen (JLU), Germany

  Dr.agr. (PhD) JLU, Germany

  Dipl.-Ing.agr. (MSc Animal Science) JLU, Germany

• Awards & Achievements

  Research Award Animal Biotechnology, Academy for Animal Health, Bonn, Germany (2004)

  Biotechnology in Animal Breeding Award, H. Wilhelm Schaumann Foundation, Hamburg, Germany (1999)

  Dissertation Award Justus Liebig University of Giessen, Germany (1990)

• Teaching Interests

  • Genetics and Epigentics
    
  • Experimental Genetics
    
  • Conservation Genetics
  • Reproductive Biotechnology
    
  • Reproductive Physiology

• Research Funding

  Research Funding last 10 years
  
  2013 - 2016
  ARC Linkage, ‘Epigenetic modifications in bovid adaptation to environmental change' A Cooper, CM Suter, M Wilkinson, S Hiendleder, B Llamas, JR Stephen, JF Taylor, DH Densham 554,000
  
  2011 - 2013
  NHMRC, ‘Preventing insulin resistance and obesity following fetal growth restriction' JA Owens, M DeBlasio, K Gatford, S Hiendleder 891,000
  
  2008 - 2012
  Qld Government Reinvestment Fund, Department of Primary Industries and Fisheries ‘Precision beef cattle production through an alternative genetic approach' B Burns, S Hiendleder, A Herring 1,350,000
  
  2007 - 2009
  NHMRC, ‘Metabolic and molecular determinants of embryo viability' M Lane, S Hiendleder, M Mitchell 531,000
  
  2006 - 2008
  EU, 6th Framework Program, ‘Cutting Edge Genomics for Sustainable Animal Breeding' S Hiendleder, E Wolf 518,000
  
  2006 - 2008
  DFG, ‘Co-culture experiments for the study of early embryo-maternal communication' S Hiendleder, M Boelhauve 215,000
  
  2005 - 2007
  BMBF, ‘Genetic and epigenetic control of bovine fetal growth' S Hiendleder, S Bauersachs, H-D Reichenbach 267,000
  
  2003 - 2005
  DFG, ‘Optimized co-culture system for bovine uterine epithelial cells' K Prelle, S Hiendleder 150,000
  

• Publications

  Publications last 10 years

  1. Bebbere D, Bauersachs S, Fürst RW, Reichenbach H-D, Reichenbach M, Medugorac I, Ulbrich SE, Wolf E, Ledda S, Hiendleder S (2013). Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus concepti and not correlated with fetal weight. PLoS One, Vol 8. No 4, e59564.
     
     
  2. Xiang R, Ghanipoor-Samami M, Johns WH, Eindorf T, Rutley DL, Kruk ZA, Fitzsimmons CJ, Thomsen DA, Roberts CT, Burns BM, Anderson GI, Greenwood PL, Hiendleder S (2013). Maternal and paternal genomes differentially affect myofibre characteristics and muscle weights of bovine fetuses at midgestation. PLoS One, Vol 8. No 1, e53402.
     
     
  3. Buckberry S, Bianco-Motto T, Hiendleder S, Roberts CT (2012). Quantitative Allele-Specific Expression and DNA Methylation Analysis of H19, IGF2 and IGF2R in the Human Placenta Across Gestation Reveals H19 Imprinting Plasticity. PLoS One, Vol 7. No 12, e51210.
     
     
  4. Kijas JW, Lenstra JA, Hayes B, Boitard S, Porto Neto LR, San Cristobal M, Servin B, McCulloch R, Whan V, Gietzen K, Paiva S, Barendse W, Ciani E, Raadsma H, McEwan J, Dalrymple B and International Sheep Genomics Consortium Members: Arranz JJ, Banos G, Beltagy AE, Benenwitz J, Bishop S, Bunger L, Calvo J, Carta A, Cemal I, Cockett N, Coltman D, D'Andrea M, Distl O, Drogemuller C, Erhardt G, Eythorsdottir E, Gill C, Gootwine E, Gupta V, Hanotte O, Heaton M, Hiendleder S, Jialin H, Kantanen J, Kent M, Longhurst T, Ma R, MacHugh D, McWilliam S, Maddox J, Malek M, Mdomar F, Miltiadou D, Moreno C, Nicholas F, Oddy VH, Pardeshi V, Pemberton J, Pilla F, Roberts C, Sechi T, Scheet P, Shariflou M, Silva P, Simianer H, Slate J, Tapio M, Vattathil S (2012). Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection. PLoS Biology, Vol 10. No 2, e1001258.
     
     
  5. Anand-Ivell R, Hiendleder S, Vinoles C, Martin GB, Fitzsimmons C, Eurich A, Hafen B, Ivell R (2011). INSL3 in the Ruminant: A Powerful Indicator of Gender- and Genetic-Specific Feto-Maternal Dialogue. PLoS One, Vol 6. No 5, e19821.
     
     
  6. Meadows JRS, Hiendleder S, Kijas JW. (2011) Haplogroup relationships between domestic and wild sheep resolved using a mitogenome panel. Heredity, Vol 106. No 4, pp 700-706.
     
     
  7. Ulbrich SE, Meyer SU, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, Büttner M, Fröhlich T, Arnold GJ, Reichenbach HD, Wolf E, Meyer HH (2011). Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy. Molecular and Cellular Endocrinology, Vol 332. No 1-2, pp 48-57.
     
     
  8. de Montera B, El Zeihery D, Müller S, Jammes H, Brem G, Reichenbach HD, Scheipl F, Chavatte-Palmer P, Zakhartchenko V, Schmitz OJ, Wolf E, Renard JP, Hiendleder S (2010). Quantification of leukocyte genomic 5-methylcytosine levels reveals epigenetic plasticity in healthy adult cloned cattle. Cellular Reprogramming, Vol 12. No 2, pp 175-181.
     
     
  9. Ng HK, Novakovic B, Hiendleder S, Craig JM, Roberts CT, Saffery R (2010). Distinct patterns of gene-specific methylation in mammalian placentas: implications for placental evolution and function. Placenta, Vol 31. No 4, pp 259-268.
     
     
  10. Burns BM, Herring AD, Laing A, Fordyce G, Bertram J, Grant T, Hiendleder S. (2010). Unrecognized variation in gestation length and birth weight of Droughtmaster calves produced through fixed-time AI. Lucy MC; Pate JL; Smith MF; Spencer, TE (Ed). 8th International Symposium on Reproduction in Domestic Ruminants. Anchorage, AK, USA, Sept 2010. Reproduction in Domestic Ruminants VII Book Series: Society of Reproduction and Fertility Vol 67. Pp 585-585.
      
      
  11. Ulbrich SE, Zitta K, Hiendleder S, Wolf E. (2010). In vitro systems for intercepting early embryo-maternal cross-talk in the bovine oviduct. Theriogenology, Vol 73. No 6, pp 802-816.
      
      
  12. Lash GE, Burton GJ, Chamley LW, Clifton VL, Constancia M, Crocker IP, Dantzer V, Desoye G, Drewlo S, Hemmings DG, Hiendleder S, Kalionis B, Keelan JA, Kudo Y, Lewis RM, Manuelpillai U, Murthi P, Natale D, Pfarrer C, Robertson S, Saffery R, Saito S, Sferruzzi-Perri A, Sobrevia L, Waddell BJ, Roberts CT. (2010). IFPA Meeting 2009 workshops report. Placenta, Vol 31. Suppl. S4-20.
      
      
  13. Novakovic B, Wong NC, Sibson M, Ng HK, Morley R, Manuelpillai U, Down T,Rakyan VK, Beck S, Hiendleder S, Roberts CT, Craig JM, Saffery R (2010). DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta. Journal of Biological Chemistry, Vol 285. No 13, pp 9583-9593.
      
      
  14. Bovine Genome Sequencing and Analysis Consortium, Elsik CG, Tellam RL, Worley KC, Gibbs RA, Muzny DM, Weinstock GM, Adelson DL, Eichler EE, Elnitski L, Guigó R, Hamernik DL, Kappes SM, Lewin HA, Lynn DJ, Nicholas FW, Reymond A, Rijnkels M, Skow LC, Zdobnov EM, Schook L, Womack J, Alioto T, Antonarakis SE, Astashyn A, Chapple CE, Chen HC, Chrast J, Câmara F, Ermolaeva O, Henrichsen CN, Hlavina W, Kapustin Y, Kiryutin B, Kitts P, Kokocinski F, Landrum M, Maglott D, Pruitt K, Sapojnikov V, Searle SM, Solovyev V, Souvorov A, Ucla C, Wyss C, Anzola JM, Gerlach D, Elhaik E, Graur D, Reese JT, Edgar RC, McEwan JC, Payne GM, Raison JM, Junier T, Kriventseva EV, Eyras E, Plass M, Donthu R, Larkin DM, Reecy J, Yang MQ, Chen L, Cheng Z, Chitko-McKown CG, Liu GE, Matukumalli LK, Song J, Zhu B, Bradley DG, Brinkman FS, Lau LP, Whiteside MD, Walker A, Wheeler TT, Casey T, German JB, Lemay DG, Maqbool NJ, Molenaar AJ, Seo S, Stothard P, Baldwin CL, Baxter R, Brinkmeyer-Langford CL, Brown WC, Childers CP, Connelley T, Ellis SA, Fritz K, Glass EJ, Herzig CT, Iivanainen A, Lahmers KK, Bennett AK, Dickens CM, Gilbert JG, Hagen DE, Salih H, Aerts J, Caetano AR, Dalrymple B, Garcia JF, Gill CA, Hiendleder SG, Memili E, Spurlock D, Williams JL, Alexander L, Brownstein MJ, Guan L, Holt RA, Jones SJ, Marra MA, Moore R, Moore SS, Roberts A, Taniguchi M, Waterman RC, Chacko J, Chandrabose MM, Cree A, Dao MD, Dinh HH, Gabisi RA, Hines S, Hume J, Jhangiani SN, Joshi V, Kovar CL, Lewis LR, Liu YS, Lopez J, Morgan MB, Nguyen NB, Okwuonu GO, Ruiz SJ, Santibanez J, Wright RA, Buhay C, Ding Y, Dugan-Rocha S, Herdandez J, Holder M, Sabo A, Egan A, Goodell J, Wilczek-Boney K, Fowler GR, Hitchens ME, Lozado RJ, Moen C, Steffen D, Warren JT, Zhang J, Chiu R, Schein JE, Durbin KJ, Havlak P, Jiang H, Liu Y, Qin X, Ren Y, Shen Y, Song H, Bell SN, Davis C, Johnson AJ, Lee S, Nazareth LV, Patel BM, Pu LL, Vattathil S, Williams RL Jr, Curry S, Hamilton C, Sodergren E, Wheeler DA, Barris W, Bennett GL, Eggen A, Green RD, Harhay GP, Hobbs M, Jann O, Keele JW, Kent MP, Lien S, McKay SD, McWilliam S, Ratnakumar A, Schnabel RD, Smith T, Snelling WM, Sonstegard TS, Stone RT, Sugimoto Y, Takasuga A, Taylor JF, Van Tassell CP, Macneil MD, Abatepaulo AR, Abbey CA, Ahola V, Almeida IG, Amadio AF, Anatriello E, Bahadue SM, Biase FH, Boldt CR, Carroll JA, Carvalho WA, Cervelatti EP, Chacko E, Chapin JE, Cheng Y, Choi J, Colley AJ, de Campos TA, De Donato M, Santos IK, de Oliveira CJ, Deobald H, Devinoy E, Donohue KE, Dovc P, Eberlein A, Fitzsimmons CJ, Franzin AM, Garcia GR, Genini S, Gladney CJ, Grant JR, Greaser ML, Green JA, Hadsell DL, Hakimov HA, Halgren R, Harrow JL, Hart EA, Hastings N, Hernandez M, Hu ZL, Ingham A, Iso-Touru T, Jamis C, Jensen K, Kapetis D, Kerr T, Khalil SS, Khatib H, Kolbehdari D, Kumar CG, Kumar D, Leach R, Lee JC, Li C, Logan KM, Malinverni R, Marques E, Martin WF, Martins NF, Maruyama SR, Mazza R, McLean KL, Medrano JF, Moreno BT, Moré DD, Muntean CT, Nandakumar HP, Nogueira MF, Olsaker I, Pant SD, Panzitta F, Pastor RC, Poli MA, Poslusny N, Rachagani S, Ranganathan S, Razpet A, Riggs PK, Rincon G, Rodriguez-Osorio N, Rodriguez-Zas SL, Romero NE, Rosenwald A, Sando L, Schmutz SM, Shen L, Sherman L, Southey BR, Lutzow YS, Sweedler JV, Tammen I, Telugu BP, Urbanski JM, Utsunomiya YT, Verschoor CP, Waardenberg AJ, Wang Z, Ward R, Weikard R, Welsh TH Jr, White SN, Wilming LG, Wunderlich KR, Yang J, Zhao FQ (2009). The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science, Vol 324. No 5926, pp 522-528.
      
      
  15. Hiendleder S, Lewalski H, Janke A (2008). Complete mitochondrial genomes of Bos taurus and Bos indicus provide new insights into intra-species variation, taxonomy and domestication. Cytogenetic and Genome Research, Vol 120. No 1-2, pp 150-156.
      Hiendleder S (2007). Mitochondrial DNA inheritance after SCNT. Advances in Experimental Medicine and Biology, Vol 591. pp 103-116.
      
      
  16. Rottmayer R, Ulbrich SE, Kölle S, Prelle K, Neumueller C, Sinowatz F, Meyer HH, Wolf E, Hiendleder S (2006). A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: morphological and functional characterization. Reproduction, Vol 132, pp 637-48.
      
      
  17. Hiendleder S, Wirtz M, Mund C, Klempt M, Reichenbach HD, Stojkovic M, Weppert M, Wenigerkind H, Elmlinger M, Lyko F, Schmitz OJ, Wolf E (2006). Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses. Biology of Reproduction, Vol 75. No 1, pp 17-23.
      
      
  18. Ulbrich SE, Rehfeld S, Bauersachs S, Wolf E, Rottmayer R, Hiendleder S, Vermehren M, Sinowatz F, Meyer HH, Einspanier R (2006). Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro. Journal of Endocrinology, Vol 188. No 2, pp 205-13.
      
      
  19. Wolf E, Hiendleder S, Bauersachs S, Fröhlich T, Sinowatz F, Blum H, Arnold GJ (2006). [Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle]. Berliner und Munchener Tierarztliche Wochenschrift. Vol 119. No 1-2, pp 7-16. German.
      
      
  20. Wolf E, Arnold GJ, Bauersachs S, Blum H, Frohlich T, Hiendleder S, Mitko K, Reichenbach, HD (2006) [Functional genome research - new strategies to improve fertility in cattle]. Zuechtungskunde Vol 78. No 6, pp 428-439. German.
      
      
  21. Flisikowski K, Maj A, Zwierzchowski L, Adamowicz T, Swito脜聞ski M, Hiendleder S, Pareek C (2006). Nucleotide sequence and variation of IGF2 gene exon 6 in Bos taurus and Bos indicus cattle. Animal Biotechnology, Vol 16. No 2, pp 203-8.
      
      
  22. Flisikowski K, Hiendleder S, Zwierzchowski L (2005). Nucleotide sequence variation in the transcription factor STAT5A 5'-noncoding region in Bos taurus and Bos indicus cattle. Biochemical Genetics, Vol 43. No 7-8, pp 459-64.
      
      
  23. Hiendleder S, Bauersachs S, Boulesteix A, Blum H, Arnold GJ, Fröhlich T, Wolf E (2005). Functional genomics: tools for improving farm animal health and welfare. In: Biotechnology Applications in Animal health and Production. MacKenzie, A.A. (Ed.). Revue Scientific et Technique, Vol 24. No 1, pp 355-77.
      
      
  24. Hiendleder S, Zakhartchenko V, Wolf E (2005). Mitochondria and the success of somatic cell nuclear transfer cloning: from nuclear-mitochondrial interactions to mitochondrial complementation and mitochondrial DNA recombination. Reproduction, Fertility and Development, Vol 17. No 1-2, pp 69-83.
      
      
  25. Hiendleder S, Bebbere D, Zakhartchenko V, Reichenbach HD, Wenigerkind H, Ledda S, Wolf E (2004). Maternal-fetal transplacental leakage of mitochondrial DNA in bovine nuclear transfer pregnancies: potential implications for offspring and recipients. Cloning and Stem Cells/Cellular Reprogramming, Vol 6. No 2, pp 150-6.
      
      
  26. Hiendleder S, Prelle K, Brüggerhoff K, Reichenbach HD, Wenigerkind H, Bebbere D, Stojkovic M, Müller S, Brem G, Zakhartchenko V, Wolf E (2004). Nuclear-cytoplasmic interactions affect in utero developmental capacity, phenotype, and cellular metabolism of bovine nuclear transfer fetuses. Biology of Reproduction, Vol 70. No 4, 1196-205.
      
      
  27. Tamassia M, Nuttinck F, May-Panloup P, Reynier P, Heyman Y, Charpigny G, Stojkovic M, Hiendleder S, Renard JP, Chastant-Maillard S (2004). In vitro embryo production efficiency in cattle and its association with oocyte adenosine triphosphate content, quantity of mitochondrial DNA, and mitochondrial DNA haplogroup. Biology of Reproduction, Vol 71. No 2, pp 697-704.
      
      
  28. Hiendleder S, Mund C, Reichenbach HD, Wenigerkind H, Brem G, Zakhartchenko V, Lyko F, Wolf E (2004) Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques. Biology of Reproduction Vol. 71 No 1, pp 217-23.
      
      
  29. Hiendleder S, Thomsen H, Reinsch N, Bennewitz J, Leyhe-Horn B, Looft C, Xu N, Medjugorac I, Russ I, Kühn C, Brockmann GA, Blümel J, Brenig B, Reinhardt F, Reents R, Averdunk G, Schwerin M, Förster M, Kalm E, Erhardt G (2003). Mapping of QTL for Body Conformation and Behavior in Cattle. Journal of Heredity, Vol 94. No 6, pp 496-506.
      
      
  30. Hiendleder S, Wolf E (2003). The mitochondrial genome in embryo technologies. Reproduction in Domestic Animals, Vol 38. No 4, pp 290-304.
      
      
  31. Wolf E, Arnold GJ, Bauersachs S, Beier HM, Blum H, Einspanier R, Fröhlich T, Herrler A, Hiendleder S, Kölle S, Prelle K, Reichenbach HD, Stojkovic M, Wenigerkind H, Sinowatz F (2003). Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk. Reproduction in Domestic Animals, Vol 38. No 4, pp 276-89.
      
      
  32. Bennewitz J, Reinsch N, Grohs C, Levéziel H, Malafosse A, Thomsen H, Xu N, Looft C, Kühn C, Brockmann GA, Schwerin M, Weimann C, Hiendleder S, Erhardt G, Medjugorac I, Russ I, Förster M, Brenig B, Reinhardt F, Reents R, Averdunk G, Blümel J, Boichard D, Kalm E (2003). Combined analysis of data from two granddaughter designs: A simple strategy for QTL confirmation and increasing experimental power in dairy cattle. Genetics, Selection, Evolution, Vol 35. No 3, pp 319-38.
      
      
  33. Kühn Ch, Bennewitz J, Reinsch N, Xu N, Thomsen H, Looft C, Brockmann GA, Schwerin M, Weimann C, Hiendleder S, Erhardt G, Medjugorac I, Förster M, Brenig B, Reinhardt F, Reents R, Russ I, Averdunk G, Blümel J, Kalm E (2003). Quantitative trait loci mapping of functional traits in the German Holstein cattle population. Journal of Dairy Science, Vol 86. No 1, pp 360-8.
      
      
  34. Hiendleder S, Zakhartchenko V, Wenigerkind H, Reichenbach HD, Brüggerhoff K, Prelle K, Brem G, Stojkovic M, Wolf E (2003). Heteroplasmy in bovine fetuses produced by intra- and inter-subspecific somatic cell nuclear transfer: neutral segregation of nuclear donor mitochondrial DNA in various tissues and evidence for recipient cow mitochondria in fetal blood. Biology of Reproduction, Vol 68. No 1, pp 159-66.

• Professional Associations

  • International Society for Animal Genetics (ISAG)
    
  • International Embryo Transfer Society (IETS)
    
  • Society for the Study of Reproduction (SSR)
    
  • Society for Reproductive Biology (SRB)

• Media Expertise

  Categories	Animals & Veterinary Science, Fertility & Reproduction
  Expertise	Animal Genetics; Animal Biotechnology; Non-Mendelian Inheritance; Epigenetics; Mitochondrial DNA; Somatic Cell Nuclear Transfer; Cloning; Embryo; Fetus; Imprinting; Gene Expression; Evolution of Domestic Animals; Sheep; Cattle

Entry last updated: Wednesday, 20 Dec 2023