BIOTECH 7001 - Drug Discovery and Development
North Terrace Campus - Semester 1 - 2023
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General Course Information
Course Details
Course Code BIOTECH 7001 Course Drug Discovery and Development Coordinating Unit School of Biological Sciences Term Semester 1 Level Postgraduate Coursework Location/s North Terrace Campus Units 3 Contact Up to 4 hours per week Available for Study Abroad and Exchange N Assumed Knowledge BIOCHEM 2500 or equivalent Restrictions Available to Graduate Certificate & Graduate Diploma in Biotechnology (Biomedical), Master of Biotechnology (Biomedical), Master of Biotechnology (Biomedical) (Advanced) and Master of Biopharmaceutical Engineering students only Assessment Oral presentation, written assignment, exam Course Staff
Course Coordinator: Dr Kate Wegener
Course Timetable
The full timetable of all activities for this course can be accessed from .
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Learning Outcomes
Course Learning Outcomes
A successful student should be able to:
1 Demonstrate an awareness of the current approaches to global drug discovery and their advantages and limitations. 2 Demonstrate an understanding of the steps involved in the drug discovery and design process 3 Demonstrate an awareness of the important contributions the different discipline areas make to the drug discovery and development process. 4 Critically analyse biological pathways for their potential as drug targets for a given disease. 5 Demonstrate the ability to use evidence-based approaches to guide decision making during the drug discovery and development process. 6 Demonstrate an understanding of the importance of strict quality control and regulation in the drug development process, and an awareness of issues associated with the manufacturing of medicines such as good manufacturing practice. 7 Critically analyse and integrate information from the scientific literature. 8 Present to an audience in summary the critical evaluation of the scientific literature and experimental data University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Attribute 1: Deep discipline knowledge and intellectual breadth
Graduates have comprehensive knowledge and understanding of their subject area, the ability to engage with different traditions of thought, and the ability to apply their knowledge in practice including in multi-disciplinary or multi-professional contexts.
2,4,6,7 Attribute 2: Creative and critical thinking, and problem solving
Graduates are effective problems-solvers, able to apply critical, creative and evidence-based thinking to conceive innovative responses to future challenges.
2,4,5,7 Attribute 3: Teamwork and communication skills
Graduates convey ideas and information effectively to a range of audiences for a variety of purposes and contribute in a positive and collaborative manner to achieving common goals.
2,3,5,8 Attribute 4: Professionalism and leadership readiness
Graduates engage in professional behaviour and have the potential to be entrepreneurial and take leadership roles in their chosen occupations or careers and communities.
1,2,3,5,6,8 Attribute 5: Intercultural and ethical competency
Graduates are responsible and effective global citizens whose personal values and practices are consistent with their roles as responsible members of society.
1,3,5,8 Attribute 6: Australian Aboriginal and Torres Strait Islander cultural competency
Graduates have an understanding of, and respect for, Australian Aboriginal and Torres Strait Islander values, culture and knowledge.
. Attribute 7: Digital capabilities
Graduates are well prepared for living, learning and working in a digital society.
2, 3, 4, 7, 8 Attribute 8: Self-awareness and emotional intelligence
Graduates are self-aware and reflective; they are flexible and resilient and have the capacity to accept and give constructive feedback; they act with integrity and take responsibility for their actions.
1,5,7,8 -
Learning Resources
Required Resources
Molecular Graphics Software
Access to the free molecular grpahics software "Chimera" is required for the drug design workshopsRecommended Resources
MyUni:
Course resources as provided including video/audio recording of lectures and copies of PowerPoint slides, as well as additional reading/recommended texts
Weblinks:
As specified during the course
Scientific literature and journal articles -
Learning & Teaching Activities
Learning & Teaching Modes
This course will be delivered by the following means:
1 or 2 x 1 hour lectures per week
1 x 2 hour workshop/tutorial per week
Workload
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.
Contact Hours (45 hours)
Lectures 18 x 1 = 18 hours
Workshops 12 x 2 = 24 hours
Exam 1 x 3 hours = 3 hours
Non-contact Hours (110 hours)
Weekly reading/other study hours per lecture = 36 hours
Preparation for workshops 2 hour per week = 24 hours
Preparation for presentations = 6 hours
Major essay = 20 hours
Exam preparation= 24 hours
Total = approximately 155 hoursLearning Activities Summary
The topics covered in the course and supported by online resources are as follows:
- Lecture 1-2: Introduction to drug discovery and target product profiles
- Lectures 3-4: High throughput screening methods.
- Lectures 5-6 Medicinal chemistry
- Lecture 7-8: Pharmacology and ADME toxicology
- Lecture 9-12: Fragments, peptidomimetics and structure based drug design
- Lecture 13: IP considerations
- Lectures 14-18: Case studies in drug discovery.
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Assessment
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Summary
Assessment Task Task Type Due Weighting Learning Outcome Quiz Formative and Summative End Week 6
5% 1-6 Target Product Profile Presentation Formative and Summative End Week 8
15% 1-8 Written Assignment Formative and Summative End Week 11 25% 4,7 Drug Design Workshop Portfolio Formative and Summative End Week 12 15% 1-3,5 End of Semester theory exam Summative In examination period 40% 1-6 Assessment Detail
Quiz (5%) - A short quiz testing the students on what they have learned from the first series of lectures.
Target Product Profile Presentation (15%) - This is a group assignment where a small group of students (4-6) investigates the drug discovery opportunities for a particular disease and develop a plan for how they would produce a therapeutic for treatment. The group presents their findings as an oral presentation.
Essay (25%) - In this individual assignment, students select a current drug discovery publication (from a provided selection) and write an essay discussing where and how the research fits into the drug discovery pipeline.
Drug Design Workshop Portfolio (15%) - In the workshops, students learn how to visualise and manipulate protein structures, as well as the basics of in silico molecular docking, using simple software on their own devices. Students then complete an online assignment, providing details about how they completed each step of the procedure and what they learned.
End of Semester Theory Exam (40%) - Students complete a three-hour exam on the theoretical concepts they have learned in lectures, as well as the application of this knowledge to the analysis of a provided research paper.Submission
Late Submission
If an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.Course Grading
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through .
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Student Feedback
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.
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Student Support
- Academic Integrity for Students
- Academic Support with Maths
- Academic Support with writing and study skills
- Careers Services
- Library Services for Students
- LinkedIn Learning
- Student Life Counselling Support - Personal counselling for issues affecting study
- Students with a Disability - Alternative academic arrangements
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Policies & Guidelines
This section contains links to relevant assessment-related policies and guidelines - all university policies.
- Academic Credit Arrangements Policy
- Academic Integrity Policy
- Academic Progress by Coursework Students Policy
- Assessment for Coursework Programs Policy
- Copyright Compliance Policy
- Coursework Academic Programs Policy
- Intellectual Property Policy
- IT Acceptable Use and Security Policy
- Modified Arrangements for Coursework Assessment Policy
- Reasonable Adjustments to Learning, Teaching & Assessment for Students with a Disability Policy
- Student Experience of Learning and Teaching Policy
- Student Grievance Resolution Process
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Fraud Awareness
Students are reminded that in order to maintain the academic integrity of all programs and courses, the university has a zero-tolerance approach to students offering money or significant value goods or services to any staff member who is involved in their teaching or assessment. Students offering lecturers or tutors or professional staff anything more than a small token of appreciation is totally unacceptable, in any circumstances. Staff members are obliged to report all such incidents to their supervisor/manager, who will refer them for action under the university's student鈥檚 disciplinary procedures.
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