成人大片

Course Outlines

BIOTECH 7001 - Drug Discovery and Development

North Terrace Campus - Semester 1 - 2019

Societies across the world are looking to combat a greater range of human diseases but at the same time contain spiralling healthcare costs. This, together with global competition and increasing regulatory standards, puts enormous pressure on the pharmaceutical industry to discover and develop a greater number of therapeutic candidates even faster and cheaper than ever before. This course develops the key themes in the drug discovery and development pipeline and highlights the multi-disciplinary nature of the research and development process. Topics include: Target identification and validation, Hit discovery, Hit-to-lead optimisation, pre-clinical and clinical testing, regulatory and manufacturing considerations.

Open All
  • General Course Information
    Course Details
    Course Code BIOTECH 7001
    Course Drug Discovery and Development
    Coordinating Unit School of Biological Sciences
    Term Semester 1
    Level Postgraduate Coursework
    Location/s North Terrace Campus
    Units 3
    Contact Up to 4 hours per week
    Available for Study Abroad and Exchange N
    Assumed Knowledge BIOCHEM 2500 or equivalent
    Restrictions Available to Graduate Certificate in Biotechnology (Biomedical), Graduate Diploma in Biotechnology (Biomedical), Master of Biotechnology (Biomedical) students only
    Assessment Tutorial presentation and participation, written assignment, exam
    Course Staff

    Course Coordinator: Dr Grant Booker

    Course Timetable

    The full timetable of all activities for this course can be accessed from .

  • Learning Outcomes
    Course Learning Outcomes
    A successful student should be able to:

    1 Demonstrate an awareness of the current approaches to global drug discovery and their advantages and limitations.
    2 Demonstrate an understanding of the steps involved in the drug discovery and design process
    3 Demonstrate an awareness of the important contributions the different discipline areas make to the drug discovery and development process.
    4 Critically analyse biological pathways for their potential as drug targets for a given disease.
    5 Demonstrate the ability to use evidence-based approaches to guide decision making during the drug discovery and development process.
    6 Demonstrate an understanding of the importance of strict quality control and regulation in the drug development process, and an awareness of issues associated with the manufacturing of medicines such as good manufacturing practice.
    7 Critically analyse and integrate information from the scientific literature.
    8 Present to an audience in summary the critical evaluation of the scientific literature and experimental data
    University Graduate Attributes

    This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:

    University Graduate Attribute Course Learning Outcome(s)
    Deep discipline knowledge
    • informed and infused by cutting edge research, scaffolded throughout their program of studies
    • acquired from personal interaction with research active educators, from year 1
    • accredited or validated against national or international standards (for relevant programs)
    		 2,4,6,7
    Critical thinking and problem solving
    • steeped in research methods and rigor
    • based on empirical evidence and the scientific approach to knowledge development
    • demonstrated through appropriate and relevant assessment
    		 2,4,5,7
    Teamwork and communication skills
    • developed from, with, and via the SGDE
    • honed through assessment and practice throughout the program of studies
    • encouraged and valued in all aspects of learning
    		 2,3,5,8
    Career and leadership readiness
    • technology savvy
    • professional and, where relevant, fully accredited
    • forward thinking and well informed
    • tested and validated by work based experiences
    		 1,2,3,5,6,8
    Intercultural and ethical competency
    • adept at operating in other cultures
    • comfortable with different nationalities and social contexts
    • able to determine and contribute to desirable social outcomes
    • demonstrated by study abroad or with an understanding of indigenous knowledges
    		 1,3,5,8
    Self-awareness and emotional intelligence
    • a capacity for self-reflection and a willingness to engage in self-appraisal
    • open to objective and constructive feedback from supervisors and peers
    • able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate
    		 1,5,7,8
  • Learning Resources
    Required Resources
    Molecular Graphics Software
    Access to the free molecular grpahics software "Chimera" is required for the drug design workshops
    Recommended Resources
    MyUni:
    Course resources as provided including video/audio recording of lectures and copies of PowerPoint slides, as well as additional reading/recommended texts

    Weblinks:
    As specified during the course
    Scientific literature and journal articles
  • Learning & Teaching Activities
    Learning & Teaching Modes
    This course will be delivered by the following means:
    1 or 2  x 1 hour lectures per week
    1 x 2 hour workshop/tutorial per week


    Workload

    The information below is provided as a guide to assist students in engaging appropriately with the course requirements.

    Contact Hours (45 hours)
    Lectures 18 x 1 = 18 hours
    Workshops 12 x 2 = 24 hours
    Exam 1 x 3 hours = 3 hours

    Non-contact Hours (110 hours)
    Weekly reading/other study hours per lecture = 36 hours
    Preparation for workshops 2 hour per week = 24 hours
    Preparation for presentations = 6 hours
    Major essay = 20 hours
    Exam preparation= 24 hours

    Total = approximately 155 hours
    Learning Activities Summary
    The topics covered in the course and supported by online resources are as follows:
    • Lecture 1-2: Introduction to drug discovery and target product profiles
    • Lectures 3-4: High throughput screening methods.
    • Lectures 5-6 Medicinal chemistry
    • Lecture 7-8: Pharmacology and ADME toxicology
    • Lecture 9-12: Fragments, peptidomimetics  and structure based drug design
    • Lecture 13: IP considerations
    • Lectures 14-18: Case studies in drug discovery.
  • Assessment

    The University's policy on Assessment for Coursework Programs is based on the following four principles:

    1. Assessment must encourage and reinforce learning.
    2. Assessment must enable robust and fair judgements about student performance.
    3. Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
    4. Assessment must maintain academic standards.

    Assessment Summary
    Assessment Task Task Type Due Weighting Learning Outcome
    Target Product Profile Presentation Formative and Summative

    End Week 8

    		  10% 1-8
    Drug Design Workshop Portfolio Formative and Summative End week 12 15% 1-3,5
    Written Assignment Formative and Summative End Week 11 25% 4,7
    End of Semester theory exam Summative In examination period 50% 1-6
    Assessment Detail
    Assessment Task Task Type Due Weighting Learning Outcome
    Target Product Profile Presentation Formative and Summative

    End Week 8

    		  10% 1-8
    Drug Design Workshop Portfolio Formative and Summative End week 12 15% 1-3,5
    Written Assignment Formative and Summative End Week 11 25% 4,7
    End of Semester theory exam Summative In examination period 50% 1-6
    Submission

    Late Submission
    If an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.

    Course Grading

    Grades for your performance in this course will be awarded in accordance with the following scheme:

    M10 (Coursework Mark Scheme)
    Grade Mark Description
    FNS   Fail No Submission
    F 1-49 Fail
    P 50-64 Pass
    C 65-74 Credit
    D 75-84 Distinction
    HD 85-100 High Distinction
    CN   Continuing
    NFE   No Formal Examination
    RP   Result Pending

    Further details of the grades/results can be obtained from Examinations.

    Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

    Final results for this course will be made available through .

  • Student Feedback

    The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.

    SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.

  • Student Support
  • Policies & Guidelines

    This section contains links to relevant assessment-related policies and guidelines - all university policies.

  • Fraud Awareness

    Students are reminded that in order to maintain the academic integrity of all programs and courses, the university has a zero-tolerance approach to students offering money or significant value goods or services to any staff member who is involved in their teaching or assessment. Students offering lecturers or tutors or professional staff anything more than a small token of appreciation is totally unacceptable, in any circumstances. Staff members are obliged to report all such incidents to their supervisor/manager, who will refer them for action under the university's student鈥檚 disciplinary procedures.

The 成人大片 is committed to regular reviews of the courses and programs it offers to students. The 成人大片 therefore reserves the right to discontinue or vary programs and courses without notice. Please read the important information contained in the disclaimer.
Top

Home

Information For

Information About

People & Places

The 成人大片
Adelaide, South Australia
5005 Australia

成人大片 Provider Number PRV12105
CRICOS Provider Number 00123M


Telephone: +61 8 8313 4455

Coordinates: -34.920843, 138.604513

Authorised by:Deputy Vice-Chancellor and Vice-President (Academic)
Maintained by:Course Outlines Administrator