BIOCHEM 3230 - Molecular & Structural Biology III (Biomed Sci)

North Terrace Campus - Semester 1 - 2016

This course combines lectures from Molecular and Structural Biology lll (BIOCHEM 3000) with practical exercises and/or laboratory placements in professional research laboratories in the first six weeks of the semester. In the last six weeks of the semester, it includes a special set of Problem Based Learning (PBL)/Tutorial exercises, not offered in any other course, which are designed to provide students with a perspective of how cutting edge biomedical science principles and techniques are applied to major research questions. This course will illustrate that cross disciplinary approaches are essential in modern biomedical science research.

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Course Details

Course Code	BIOCHEM 3230
Course	Molecular & Structural Biology III (Biomed Sci)
Coordinating Unit	School of Biological Sciences
Term	Semester 1
Level	Undergraduate
Location/s	North Terrace Campus
Units	6
Contact	Up to 23 hours per fortnight
Available for Study Abroad and Exchange	N
Prerequisites	BIOCHEM 2500 & BIOCHEM 2501
Incompatible	BIOCHEM 3000
Restrictions	Available to BSc(BiomedSc) students only
Assessment	Exam, Practical Reports, PBL exercises & online assessment

Course Staff

Course Coordinator: Dr John Bruning

Course Timetable

The full timetable of all activities for this course can be accessed from .

Course Learning Outcomes

1	Understanding aspects of protein structure and function including protein folding, degradation, development of new therapies, molecular interactions and recognition.
2	Understanding aspects of the control of gene expression including genetic circuits, chromatin structure and remodelling, gene promoter assembly, eukaryotic mRNA synthesis, processing and translation.
3	Understanding key experimental processes required to evaluate protein structure, function and gene expression, and knowledge of how to apply them to solve specific biochemical problems.
4	Specific skills in planning, performing, interpreting, quantitatively analysing and communicating biochemical research using a variety of modern experimental techniques.
5	Ability to find, read, interpret and critically analyse relevant scientific literature.
6	Ability to work in teams and communicate scientific outcomes.

University Graduate Attributes

This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:

University Graduate Attribute	Course Learning Outcome(s)
Deep discipline knowledge informed and infused by cutting edge research, scaffolded throughout their program of studies acquired from personal interaction with research active educators, from year 1 accredited or validated against national or international standards (for relevant programs)	1, 2, 3
Critical thinking and problem solving steeped in research methods and rigor based on empirical evidence and the scientific approach to knowledge development demonstrated through appropriate and relevant assessment	3, 4, 5
Teamwork and communication skills developed from, with, and via the SGDE honed through assessment and practice throughout the program of studies encouraged and valued in all aspects of learning	4, 5, 6
Career and leadership readiness technology savvy professional and, where relevant, fully accredited forward thinking and well informed tested and validated by work based experiences	5, 6
Intercultural and ethical competency adept at operating in other cultures comfortable with different nationalities and social contexts able to determine and contribute to desirable social outcomes demonstrated by study abroad or with an understanding of indigenous knowledges	6
Self-awareness and emotional intelligence a capacity for self-reflection and a willingness to engage in self-appraisal open to objective and constructive feedback from supervisors and peers able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate	4, 6

Learning Resources

Required Resources

Laboratory coat, safety glasses and closed shoes.

Recommended Resources

Text book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science

Online Learning

Resource material such as lecture, tutorial, practical and past exams will be available on Myuni.
Online assessment will be conducted via Myuni.

Learning & Teaching Modes

This course will be delivered by the following means:

3 Lectures (same lectures as BIOCHEM 3000) of 1 hour each per week.

1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.

1 Practical of 15 hours per fortnight for the first 6 weeks of the semester. (Odd weeks = 5 hours & Even weeks = 10 hourduration) Includes 1 oral presentation in weeks 6, with immediate feedback provided.

3 X 5 hour problem based learning (PBL) workshop per fortnight for the final six weeks of the semester.

3 online multiple choice tests of 1 hour duration per semester (weeks 4, 8 and 12, with immediatefeedback provided).

Workload

The information below is provided as a guide to assist students in engaging appropriately with the course requirements.

A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).

Learning Activities Summary

Schedule Week	Topic	Lecture
1	Protein Life Cycle	Lecture
2	Introduction to Macromolecular X-ray Crystallography	Lecture
3	Applications of Structural Biology/Proteomics	Lecture
4	Proteomics/Protein-nucleic Acid Interactions	Lecture
5	Genetic Circuits and Synthetic Biology	Lecture
6	Genetic Circuits and Synthetic Biology	Lecture
7	Chromatin Remodelling and Transcriptional Control	Lecture
8	Chromatin Remodelling and Transcriptional Control	Lecture
9	How TranscriptionFactors are Regulated to Control Complex Promoters	Lecture
10	How TranscriptionFactors are Regulated to Control Complex Promoters	Lecture
11	RNA Processing	Lecture
12	RNA Processing	Lecture

The University's policy on Assessment for Coursework Programs is based on the following four principles:

Assessment must encourage and reinforce learning.
Assessment must enable robust and fair judgements about student performance.
Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
Assessment must maintain academic standards.

Assessment Summary

Assessment tasks	Type of Assessment	Percentage of total assessment for grading purposes	Hurdle	Outcome being assessed
Practical report	summative	15	no	4, 5, 6
PBL report	summative	15	no	4, 5, 6
Online tests	summative	5	no	1, 2
Exam	summative	65	no	1, 2, 3

Assessment Related Requirements

Attendance and active participation at all practicals is mandatory

Assessment Detail

End of semester written Exam (65% of total course grade): 3 hour examination covering the lecture material. It is made up of a mixture of short and long answer type questions.

Practical write up (15% of total course grade): The six week long practical exercise will include

experimental work, keeping an up to date laboratory notebook, 1 oral presentation and the submission of a final practical report. The oral presentation is 10-15 minutes, cover the research performed in the practical, and performed in small groups in week 6. Students receive feedback throughout the semester on laboratory performance and keeping of laboratory notebooks,

immediately after the oral presentation, and on the final report. Outstanding students may have the option of a laboratory-based research project in place of the practical exercise.

PBL, final six weeks of the semester: (15% of total course grade): A specialised set of Problem Based Learning (PBL)/Tutorial exercises, are designed to provide students with a perspective of how cutting edge biomedical science principles and techniques are applied to major research questions. This

will illustrate that cross disciplinary approaches are essential in modern biomedical science research.

Online exercises: Three multiple choice tests in weeks 4, 8 and 12 (5% of total course grade). Encourages revision of the material soon after the relevant lectures, and immediate feedback provided to students.

Submission

If an extension is not applied for, or not granted,then a penalty for late submission
will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.

Course Grading

Grades for your performance in this course will be awarded in accordance with the following scheme:

M10 (Coursework Mark Scheme)
Grade	Mark	Description
FNS		Fail No Submission
F	1-49	Fail
P	50-64	Pass
C	65-74	Credit
D	75-84	Distinction
HD	85-100	High Distinction
CN		Continuing
NFE		No Formal Examination
RP		Result Pending

Further details of the grades/results can be obtained from Examinations.

Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

Final results for this course will be made available through .

Student Feedback

The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.

SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.

Provision of Feedback to Students
The assessor usually provides appropriate feedback of assessment tasks to the student by means of
written comments. The student has the opportunity to directly liaise with the assessor to obtain additional feedback and clarification if required.
Student Support
Policies & Guidelines
This section contains links to relevant assessment-related policies and guidelines - all university policies.
Fraud Awareness

Students are reminded that in order to maintain the academic integrity of all programs and courses, the university has a zero-tolerance approach to students offering money or significant value goods or services to any staff member who is involved in their teaching or assessment. Students offering lecturers or tutors or professional staff anything more than a small token of appreciation is totally unacceptable, in any circumstances. Staff members are obliged to report all such incidents to their supervisor/manager, who will refer them for action under the university's student鈥檚 disciplinary procedures.

The 成人大片 is committed to regular reviews of the courses and programs it offers to students. The 成人大片 therefore reserves the right to discontinue or vary programs and courses without notice. Please read the important information contained in the disclaimer.

Authorised by:	Deputy Vice-Chancellor and Vice-President (Academic)
Maintained by:	Course Outlines Administrator

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