成人大片

Name	Role	Building/Room	Email
Assoc. Prof. Chris Ford	Course Coordinator	WIC 4.43, Waite Campus	christopher.ford@adelaide.edu.au
Dr Cindy Bottema	Lecturer assisting	G15, JS Davies Building, Roseworthy Campus	cynthia.bottema@adelaide.edu.au
Dr Beth Loveys	Teaching	G26, Charles Hawker Building, Waite Campus	beth.loveys@adelaide.edu.au

1	Describe the role of thermodynamics in the determination of biochemical reactivity and differentiate between the kinetic and thermodynamic factors influencing biochemical reactions.
2	Explain how protein structure and function is derived from the constituent amino acids, and compare the features of structural and globular proteins.
3	Describe the basic principles governing the rate of enzyme catalysed reactions and the forms of inhibition of enzyme-catalysed reactions.
4	Describe the major pathways of carbohydrate and lipid metabolism and demonstrate how energy is stored and released through them.
5	Explain how the functional diversity of lipids is derived from their composition.
6	Describe the basic features of the cellular metabolism of amino acids and nucleic acids.
7	At the end of this course, students will have demonstrated familiarity and competence with the practical skills and techniques used in biochemical research and analysis. This will include experimental planning, the preparation of reagents and use of basic instrumentation (spectrophotometers, centrifuges, chromatographic apparatus etc), the collection of biochemical data and its presentation, and most importantly, the analysis and interpretation of the outcomes of biochemical investigations.
8	At the end of this course, students will have demonstrated the ability to undertake the research, preparation and delivery of presentations of biochemical topics selected to reinforce and augment the material presented in lectures.

There is no required textbook for this course.

The recommended text for this course is Tymoczko, Stryer and Berg (2012) Biochemistry A Short Course 2^nd Edition. 

Advanced treatment of topics covered during the course will be found in many of the major undergraduate biochemical textbooks. Students seeking further details and greater coverage of topics than are provided by the recommended text are encouraged to consider supplementing their study using one of these. Other good biochemistry texts include:

• Nelson and Cox (2012) Lehninger’s Principles of Biochemistry 6^th Edition
• Berg, Tymoczko and Stryer (2006) Biochemistry 6^th Edition
• Mathews, Van Holde and Ahern (2000) Biochemistry.

A limited number of copies of some of these texts will be held on Reserve in the Waite library.

The publisher (WH Freeman and Company) offers a range of eBook options for access to the texts by Tymoczko et al., Berg et al. and Nelson & Cox. Some of these may be available for use by Australian students

A shorter biochemistry ebook suitable for Kindle readers or the Kindle App on iPads etc, Instant Notes in Biochemistry 2^nd Edition, by David Hames, is available for purchase or short-term rental from the Kindle store. While this book does not cover topics in the depth provided by any of the major textbooks mentioned above, it nonetheless provides a useful background to all of the topics covered in the course.

 A reading list of references relevant to topics covered in the course, which in many instances will provide the research context around these topics, is provided and can be accessed from MyUni. Individual articles contained on the reading list may be downloaded for private study. From time to time during the course, lecturing staff, tutors etc may suggest that you read additional scientific papers. These will be made available for online reading and download via MyUni; full details will be given as appropriate.

MyUni: Teaching materials and course documentation will be posted on the MyUni website ().

Course administration is accomplished using MyUni: activities will include email, Announcements, lecture handouts and recordings, an online reading list and links to past examinations. Coursework assignments may be submitted through Turnitin as directed. Coursework marks will be made available through the Gradebook. Assessment in the form of online quizzes will be offered during the semester as a part of the Formative Assessment component.  All materials will be released at the relevant time during the semester.

Online activities for use before practical classes will be delivered using Learning Activity Management System (LAMS).

Lectures:

There are three lectures (each of 1 hour duration) per week, the first hour of lectures may be used to revise the previous week's lecture material.

Lecture notes will be posted to MyUni a few days in advance of the respective lecture and will not generally be provided to students in hard copy. Every attempt will be made to record lectures, and to make them available for streaming and download from MyUni.

A student enrolled in a 3 unit course, such as this, should expect to spend, on average 12 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., pre-class preparation, post-class assessments, reading and revision).

Schedule

Week	Type of learning activity	Topic
Week 1	Lecture	Course introduction; Biochemistry in Context: basic principles of biochemical activity – 1 lecture. Protein structure and function - 2 lectures.
	Practical	Analysis of nitrite.
	Tutorial or other activity	Biochemical calculations.
Week 2	Lecture	Protein structure and function revisited  – 1 lecture; Enzyme structure and function - 2 lectures.
	Practical	Analysis of nitrite.
	Tutorial or other activity	Biochemical calculations.
Week 3	Lecture	Online test - 1 lecture. Lipid biochemistry I and II - 2 lectures.
	Practical	Analysis of soluble carbohydrates.
	Tutorial or other activity	Proteins and enzymes.
Week 4	Lecture	Lipid biochemistry III, IV and V - 3 lectures.
	Practical	Analysis of soluble carbohydrates.
	Tutorial or other activity	Proteins and enzymes.
Week 5	Lecture	Lipid biochemistry VI and VII - 2 lectures. Lipids and nutritional outcomes - 1 lecture.
	Practical	Starch extraction and analysis.
	Tutorial or other activity	No tutorials.
Week 6	Lecture	No lectures - Mid-semester summative assessment (exam) - 2 hours.
	Practical	Starch extraction and analysis.
	Tutorial or other activity	No tutorials.
Week 7	Lecture	Cellulosic biofuels - 1 lecture. Carbohydrate biochemistry I and II - 2 lectures.
	Practical	Team Based Learning Activity 1.
	Tutorial or other activity	Team Based Learning Activity 1.
Week 8	Lecture	Carbohydrate biochemistry revisited - 1 lecture. Introduction to metabolism - 2 lectures.
	Practical	Team Based Learning Activity 2.
	Tutorial or other activity	Team Based Learning Activity 2.
Week 9	Lecture	Glycolysis and its regulation - 2 lectures. Pathways to the production of low-alcohol wines - 1 lecture.
	Practical	Ion-exchange chromatography.
	Tutorial or other activity	5-minute Big-Bang Biochemistry.
Week 10	Lecture	Glycolysis revisited - 1 lecture. TCA cycle and oxidative phosphorylation - 2 lectures.
	Practical	Ion-exchange chromatography.
	Tutorial or other activity	5-minute Big-Bang Biochemistry.
Week 11	Lecture	Photosynthetic electron transfer - 1 lecture. Alternative modes of glucose metabolism - 2 lectures.
	Practical	Enzyme kinetics.
	Tutorial or other activity	Metabolism.
Week 12	Lecture	Metabolic pathways revisited - 1 lecture. Amino acid and nucleic acid metabolism - 2 lectures.
	Practical	Enzyme kinetics.
	Tutorial or other activity	Metabolism.

PRACTICAL SESSION CODE OF CONDUCT All students must follow these rules in practical exercises:

• No eating, drinking, application of makeup, etc in laboratories; no water bottles or items of food or drink may be visible in laboratories; mobile phone calls to be taken and made outside the laboratory only.
• Closed shoes must be worn at all times in all practical exercises, wherever they are held.
• Lab coats and other personal protective equipment must be worn at all times in laboratories or other areas whenever students are instructed to wear them; these should be removed when leaving the laboratory.
• Bags, coats, etc. that are brought into a lab must be placed under the bench to avoid causing obstructions. • All containers used during a practical session must be labelled, including water and other common non-toxic substances.
• Report all accidents, personal or involving experimental materials, to the person in charge.
• Playing around in a laboratory and many other work areas is dangerous; participants in improper behaviour will be asked to leave.
• Students must dispose of materials as directed.
• Students must wash their hands upon departing the labs and other work areas.
• Students must clean and tidy their bench and/or work area before departure; benches and/or work areas will be inspected at the end of each practical session.
• Students not complying with the rules will not receive credit for the practical session in which the breach occurred.

No elements of the course have a formal exemption from the requirements of the Assessment for Coursework Programs Policy.

Assessment task	Task type	Due	Weighting	Learning Outcome
Practical report - carbohydrate analysis	Summative/Formative	Week 6 or end first week mid-semester break	5%	7
Practical report - ion-exchange chromatography	Summative/Formative	Week 11 or 12	10%	7
Practical skills and biochemical calculations - Online test	Summative/Formative	Week 3	5%	7
Laboratory notebook	Summative/Formative	Week 12 or 13	5%	7
Online quizzes	Summative/Formative	Ongoing during semester	5%	1,2,3,4,5,6
5-minute Big-Bang Biochemistry	Summative/Formative	Weeks 9 or 10	5%	2,3,4,5,6,8
Tutorial team work	Summative/Formative	Weeks 1 or 2, 3 or 4, 11 or 12	5%	1 to 6; 8
Team-Based-Learning	Summative/Formative	Weeks 7 and 8	10%	2,3,4,8
Mid-semester assessment	Summative/Formative		25%	1,2,3,5
Exam	Summative		25%	4,6

Attendance at practicals and tutorials is compulsory; it is not acceptable to leave part-way through classes.

To pass the course students must gain an overall scaled mark of at least 50% when the marks for the Summative and Formative components are added together.

Hurdle requirements:

Students must achieve at least 40% of the total marks for the Summative Assessment component, i.e. a combined mark of not less than 72/180 for the mid-semester assessment and the end of semester examinations.

Summative (examination-based) Assessment - details:

The mid-semester assessment will consist of a 2-hour paper containing questions based on lecture and tutorial material covered in the preceding weeks. All questions must be answered.

The examination in the Semester 1 exam period ( the 'final exam') will consist of a 2-hour paper, containing questions derived from lectures and tutorials delivered after the mid-semester examination. All questions must be answered. Note: TBL tutorial topics will NOT be re-examined in the final exam.

To pass the summative assessment component of the course, a student must achieve a total score for the two papers of at least 72/180 marks.

Formative (coursework) Assessment - details:

Formative assessment for the course will be covered by the following items:

1. Practical class reports, laboratory book presentation and online test:

a. There will be five practical classes conducted per student over the course of the semester. Each of these will incorporate assessment of work, submitted as a formal write-up no later than 1 week after the class (carbohydrate analysis and ion-exchange practical classes) or by submission of the laboratory notebook in weeks 12 or 13. All submitted work will be returned with feedback within 2 weeks of submission.

b. You will be supplied with a laboratory notebook and detailed instructions on its use. The notebooks will be checked at intervals during the course and assessed in weeks 12 or 13. The marks awarded for the laboratory notebook will be added to those for the practical assessments.

c. An online test will be held during the first lecture period in week 3 (0910-1000). The test will comprise questions covering the biochemical calculations and basic practical skills encountered in weeks 1 and 2.

2. Tutorial assessments: Tutorials will take the format of team learning. Tutorial classes will be held in weeks 1/2, 3/4 and 11/12. You will be allocated to teams at the beginning of semester. Six tutorial questions will be posted to MyUni a few days before the class. Each team will be informed of the question they are required to answer at the start of the tutorial class, and will have approximately one hour to prepare their team's answer. Two members of the team will then present this answer to the whole class. Students will be assessed on their team's answer.

There will also be two whole class Team Based Learning (TBL) exercises during the semester, in which you will be provided with some learning materials prior to the class that will provide you with the background knowledge for the TBL topic under consideration. The TBL class itself will begin with a series of 'single-best-answer' questions based on the pre-class learning material, which will be answered individually by each of you. You will then join your team members, and working together, provide answers to the same SBA questions. The answers will be revealed and an opportunity for discussion and clarification of any areas of confusion will occur. Subsequently, still working in your teams, you will be presented with a series of SBA questions based on one or more scenarios developed from the topics under study, and will provide answers to these in a class-based settting.

3. Online quizzes: During the semester, 5 online quizzes will be set from within MyUni/Assessments. Each quiz will contain between 10 and 20 questions, which will comprise a number of formats including but not limited to multiple choice, missing words, ordering and calculations. Quizzes will normally be available for a four-day period including weekends, which will be announced via a MyUni Announcement and email to each student.

The quizzes are intended to provide each student with a brief assessment of their knowledge of topics covered in recent and past lectures and tutorials. Each quiz may be attempted only once; you will receive full answers upon completion of the quiz.

4. 5-Minute Big-Bang Biochemistry: Students, working in pairs, will make a 5-minute presentation to the class. This will follow the format of the national ‘Three Minute Thesis’ (3MT) competition, in which PhD students re required to provide a ‘snapshot’ of the background and relevance of their PhD project research to an ‘educated but non-specialised’ audience. You will be expected to choose a partner from within your tutorial session (ie 'odd' or 'even' weeks); topics will be allocated by the tutors. The ‘rules’ are relatively simple – five minutes, one PowerPoint slide per student, no animations or transitions.

 

Late submission of assessments

If an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days or more late without an approved extension can only receive a maximum of 50% of the mark.