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Biophysical Chemistry: ‘Physical Chemistry for the Biosciences’, (Chang, 1st Edition, University Science Books, 2005) ISBN: 1891389335

Bioinorganic Chemistry: ‘Inorganic Chemistry’ (Shriver & Atkins, 3rd Edition, Oxford University Press, 1999) - later edition available as well

Medicinal Chemistry: ‘An Introduction to Medicinal Chemistry’ (G. L. Patrick: 3rd Edition, Oxford University Press, 2005)

Bioorganic Chemistry: To be announced.

MyUni: Teaching materials and course documentation will be posted on the MyUni website ().

Lectures 36 x 50-minute sessions with three sessions per week

Tutorials 11 x 50-minute sessions with one session per week

Practicals 8 x 5-hour sessions

A student enrolled in a 3 unit course, such as this, should expect to spend, on average 12 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).

The course content includes the following:

Bio-thermodynamics and Enzyme Kinetics.
Role of thermodynamics and kinetics with specific applications in drug binding, dialysis and osmosis.

Metalloproteins and Enzymes
An introduction to the arena of biomimetic inorganic chemistry will be presented, including extensive discussion of the structure and function of metalloenzymes. This section will emphasise how the principles of nature can be applied to the rational design of metallic species capable of controlled nitrogen, carbon dioxide, carbon monoxide and methane activation.

Principles of Medicinal Chemistry
An introduction to the principles of medicinal chemistry including synthesis, natural product isolation, lead generation, lead optimisation and quantitative structure-activity relationships will be presented. The principles of parallel and combinatorial synthesis will be presented in this context.

Natural Products and Bio-Polymers
DNA/RNA, terpenes and alkaloids. Concept of natural molecules as targets and leads. Introduction to the biosynthesis of these compounds.

Practicals
The practical exercises will provide students with "hands on" experience in the synthesis and analysis of molecules of medicinal and biological relevance.

Tutorials
Tutorials will be used to reinforce the concepts introduced in lectures.

Practical work is compulsory – This includes conduct of required experimental work, attendance at demonstrator interviews (as required) and submission of the laboratory reports.

To pass this course students must:

• Attain a minimum of 60% for the practical reports:
  Students who do not attain this minimum requirement will not be offered an additional assessment.
• Attain a minimum of 45% for the exam:
  Students who attain a final course grade of at least 45% but do not attain a minimum of 45% for the exam may be offered an Additional Academic Exam during the Replacement/Additional Assessment period, in line with the Modified Arrangements for Coursework Assessment Policy.

Assignments
This assessment activity specifically covers lecture course content and is designed to encourage students to engage with the subject matter through the semester (4 short-answer assignments). The assignments are supported and enhanced by students’ participation in tutorials.

Extended Practical Report
This assessment activity addresses the scientific communication aspects in the chemical laboratories. Students will write the extended practical report based on the contents in one of the short practical reports.

Practical Reports
This assessment activity comprehensively addresses the practical aspects of chemistry and competent training in the techniques employed in chemical laboratories (8 short, hand-written practical r eports submitted in class).

An opportunity to make-up a maximum of one missed practical session may be offered during the semester. Students must contact the Course Coordinator as soon as possible if they have missed their practical as practical classes are often full and additional space is often unavailable.

Final exam
This assessment activity comprehensively addresses the learning outcomes

Submission of Assigned Work
Coversheets must be completed and attached to all submitted work. Coversheets can be obtained from the School Office (room G33 Physics) or from MyUNI. Work should be submitted via the assignment drop box at the School Office.

Extensions for Assessment Tasks
Extensions of deadlines for assessment tasks may be allowed for reasonable causes. Such situations would include compassionate and medical grounds of the severity that would justify the awarding of a supplementary examination. Evidence for the grounds must be provided when an extension is requested. Students are required to apply for an extension to the Course Coordinator before the assessment task is due. Extensions will not be provided on the grounds of poor prioritising of time. 

Late submission of assessments
If an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days or more late without an approved extension can only receive a maximum of 50% of the mark.