成人大片

Course Coordinator: Dr Ian Musgrave
Phone: +61 8 8313 3905
Email: ian.musgrave@adelaide.edu.au
Location: Room S515, Medical School South

Additional Academic Staff

Dr Scott Smid
Phone: +61 8 8313 5287
Email: scott.smid@adelaide.edu.au
Location: Room N531, Medical School North

Dr Abdallah Salem
Phone: +61 8 8313 4327
Email: abdallah.salem@adelaide.edu.au
Location: Room N506, Medical School North

Dr Janet Coller
Phone: +61 8 8313 3906
Email: janet.coller@adelaide.edu.au
Location: Room N515, Medical School North

School Office
Phone: +61 8 8313 5571
Email: medical.sciences@adelaide.edu.au
Location: Room N131a, Medical School North

1	Recognise the fundamental principles of drug actions at their target sites (eg. receptors, enzymes etc)
2	Describe the different types of pharmacodynamic interactions of drugs with receptors and apply quantitative methods to analyse such interactions
3	Explain the functioning of the autonomic nervous system at a pharmacological, anatomical and physiological level, with an integrated approach to its role in physiological homeostasis
4	Compare the functional roles of selected central nervous system transmitters and be able to list clinically important drugs acting at these pharmacological systems
5	Describe the processes and staging of drug discovery
6	Choose a relevant experimental system to test experimental hypotheses (e.g. in vitro or in vivo; animal species etc)
7	Design experiments which are properly controlled and which use appropriate statistical methods of data analysis
8	Work co-operatively in a small group setting to conduct experiments, generate, analyse and interpret experimental data
9	Consider ethical issues when designing experiments using humans or animals
10	Consider the importance of method validation, and the recognition of experimental errors

Textbook: Rang H.P., Dale, M.M., Ritter, J.M and Flower, R.J. and Henderson, G. Pharmacology, 7th Ed., 2012. Elsevier. ISBN 978-0-7020-3471-8.

Supplemental Textbooks:

Joel G. Hardman, Lee E. Limbird, consulting editor Alfred Goodman Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 11th Ed., New York: McGraw-Hill, 2006.

Katzung B.G. Basic and Clinical Pharmacology, 10th Ed., New York: Prentice Hall, 2007.

Julien, Robert M. Title: A Primer of Drug Action, 11th Ed. Worth Publishers.

All course materials will be provided online via MyUni, including lecture notes in either pdf or powerpoint format, relevant lab and tutorial handouts and other supporting materials as required. Audio recordings to lectures may be provided at the discretion of academic staff.

This course is comprised of a combination of didactic lectures, interactive tutorial sessions and prescribed laboratory group-based practical sessions. Tutorials are designed to support the major learning objectives set in the lecture content and require student interaction. Group-based laboratory practicals are designed to reinforce and extend on learning provided in the themed lecture content as well as providing an understanding and proficiency in research methods and experimental design, data analysis and write-up.

The information below is provided as a guide to assist students in engaging appropriately with the course requirements. The total weekly workload for this course is 24 hours per week; as a guide it is comprised of the following activities:

Lectures including preparation: 6 hours p.w.
Tutorials including preparation: 6 hours p.w.
Laboratory practicals including preparation and report writing: 10 hours p.w.
Exam and test revision: 2 hours p.w.

Pharmacodyamics, 4 lectures – Dr Janet Coller Transmitter Systems & Drug Action, 3 lectures – Dr Scott Smid; 3 lectures – Dr Abdallah Salem
Receptors & Signal Transduction – 6 lectures, Dr Ian Musgrave
Drug Abuse and Addiction – 3 lectures- Dr Abdallah Salem; 3 lectures -Dr Janet Coller
Drug Discovery (Preclinical) 6 lectures - Dr Scott Smid; 3 lectures- Dr Ian Musgrave

Tutorial classes are based on the themed lecture content above and are usually set to follow the completion of lecture delivery within the prescribed theme. Additional tutorial content is delivered in the areas of drug calculations and dilutions and biostatistics, which are topics that reinforce aspects of teaching in the practical classes.

Practical classes:

Session 1- Analytical (quantitative) Methodology
Session 2- Agonist/Antagonist activity in isolated tissues
Session 3- Receptor tolerance
Session 4- Adrenoceptors
Session 5- Receptors & Signal Transduction
Session 6- Drug actions In Vivo CNS I
Session 7- Drug actions In Vivo CNS II

Week	Topic	Lecturer
Week 1	Pharmacodynamics	Janet Coller
Week 2	Pharmacodynamics	Janet Coller
Week 3	Transmitter systems and drug action	Scott Smid
Week 4	Transmitter systems and drug action	Abdallah Salem
Week 5	Receptors and Signal transduction	Ian Musgrave
Week 6	Receptors and Signal transduction	Ian Musgrave
Week 7	Drug Abuse and Addiction	Abdallah Salem
Week 8	Drug Abuse and Addiction	Janet Coller
Week 9	Chemotherapy	Scott Smid
Week 10	Drug Discovery	Scott Smid, Ian Musgrave
Week 11	Drug Discovery	Ian Musgrave
Week 12	Drugs Discovery	Scott Smid

Laboratory Conduct

1. PROTECTIVE CLOTHING (LABORATORY COATS and SAFETY GLASSES) MUST BE WORN IN THE LABORATORY. Thongs should not be worn, and bare feet are absolutely prohibited (danger from glass and spillage).
2. Wash your hands before meals or on leaving the laboratory for any reason.
3. All possible precautions should be taken when handling body fluid, to prevent spread of any type of infection. These are:
   1. prevent aerosol production (e.g. never mix the fluids with hot water)
   2. use disposable gloves;
   3. wash hands after handling biological samples;
4. Avoid contaminating your hands, face or clothes, or the benches, chairs, stools, notebooks, floors, door-handles, switches, gas, water, pressure, vacuum or other taps, with animal excreta, toxins, chemicals or drugs. Other people have to handle things you may have touched. Don't suck pencils or anything similar in the laboratory.
5. No food or drink should be consumed or brought into the laboratory.
6. No smoking should take place in the laboratory.
7. All solutions should be treated with care. Any material, dry or in solution, spilt on to the bench, the floor, or the hands should be cleaned up at once with disposable paper towels. Spills should be cleaned up immediately and hands washed after any inadvertent contact.
8. No drug or syringe must leave the department for any reason.
9. All sharps (hypodermic needles, scalpel blades) must be placed in the yellow sharps disposal bins placed around the laboratory.
10. Solid waste should be placed in the appropriate bins, not in the sink.
11. Students should pay particular attention to the care of animals. The ethical aspects of using animals and techniques for handling and injecting animals will be demonstrated.
12. Any equipment failure or other faults should be reported to a demonstrator or to a technician.
13. At the conclusion of the experiment, it is the student’s responsibility to tidy the work space and to ensure that tubes, tips etc are disposed of in the appropriate bins provided.

No unauthorised persons are to visit students while working in the laboratory.

Assessment Task	Assessment Type	Weighting	Learning Outcome(s) being addressed
Final exam	Summative	50%	1-8
Assessment Test I (Lecture content)	Summative	10%	1-8
Assessment Test II (Practical content)	Summative	10%	8-10
Laboratory Practical Reports	Summative	30%	8-10

Important notes on Laboratory Practical Assessment

In this course emphasis is placed on competence in laboratory practicals. Attendance is compulsory and a failure to attend a minimum number of practical sessions may impact on your ability to successfully complete the pharmacology course. If you miss more than two practical sessions for the semester you may be at risk of not completing the course requirements. Due to the nature of our lab practicals it is impossible to reschedule practical classes (i.e. you cannot make them up until the course is next run in the following year). If you have a minor study clash (eg. of not more than 1 hour) you should discuss this with the course coordinator in advance, as a reasonable alternative arrangement may be made where possible.

If you miss a practical session e.g. from illness, you are required to present medical or compassionate certification. Such certificates need to be provided to The Course Coordinator directly within one week of the practical session date. Submission of a practical report without a valid certificate will result in a 0 mark accorded.

Final exam: summative; due at end of semester; 50% weighting.

Assessment test I: summative; due week following mid-semester break.

Assessment test II: summative; due from weeks 10-12.

Laboratory Practical reports: formative & summative; due weekly from semester weeks 2-9; 30% weighting.

Final Exam

Marks attained during a 3 hour written paper held during exam week at the end of semester will test a student’s understanding of the knowledge of lecture and tutorial content in its entirety, as assessed using a combination of multiple choice, short answer and essay-style questions.

Coursework and Practical Component:

The remaining 50% of the final grade is assigned on the basis of performance during the practical course (based on laboratory reports) in addition to Assessment Tests I (all lecture material delivered prior to mid-semester break) and II (written test on theory and experimental design specifically related to laboratory practicals).

Assessment Tests:

There will be two Assessment Tests during Semester 1. They will be based on lecture and practical material, respectively. They will consist of multiple choice questions and short answer questions.

Test I covers lecture and tutorial content only from week 1 to the mid-semester break. It is normally held either just prior to, or immediately following, the mid semester break. It provides a useful mid-way guide to your progress in understanding course material.

Test II covers aspects of practical theory from the Practical Sessions. This is written test based on your comprehension of experimental design, analysis and interpretation of data specifically related to laboratory practicals. You do not need to memorise actual raw data from your lab sessions in this test.
aw data from your lab sessions in this test.

All written submissions (e.g. practical reports) must be accompanied by a signed School of Medical Sciences cover sheet. Proforma cover sheets will be available for download off MyUni. Mail boxes for written submission are located near The School of Medical Sciences Front Office, on level 1, Medical School North.

The late submissions penalty is set by The School of Medical Sciences on all submittable items and is noted as follows:

3rd Year Courses: 30% of total available points will be penalised per day (24 hour period or fraction thereof). An automatic zero mark will be applied after 3 days.

If you miss an assessment test e.g. from illness, you are required to present medical or compassionate certification to be eligible to sit a supplementary test. Such certificates need to be provided to The Course Coordinator directly within one week of the test date. The date and time of the supp. test is then determined by the Course Coordinator and is not negotiable. Students will be informed of the supp. test date by email.

Turn-around times for marking lab practical reports and marked assessment tests are normally 1-2 weeks from date of submission or sitting.